Reactive aqueous two-phase systems for the production and purification of PEGylated proteins
Background: PEGylation, defined as the covalent attachment of polyethylene glycol, allows the synthesis of PEGylated therapeutic proteins with enhanced physicochemical properties. Traditional alkylating N-terminal PEGylation reactions on amine groups involve the use of modified linear mono-methoxy p...
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Formato: | article |
Lenguaje: | EN |
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Elsevier
2021
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Acceso en línea: | https://doaj.org/article/bd7998d3b2444c5fbfeb010764a512ed |
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