Tenomodulin expression in the periodontal ligament enhances cellular adhesion.
Tenomodulin (Tnmd) is a type II transmembrane protein characteristically expressed in dense connective tissues such as tendons and ligaments. Its expression in the periodontal ligament (PDL) has also been demonstrated, though the timing and function remain unclear. We investigated the expression of...
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2013
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oai:doaj.org-article:bd83723b418445a08895948e1c17d2e22021-11-18T07:49:52ZTenomodulin expression in the periodontal ligament enhances cellular adhesion.1932-620310.1371/journal.pone.0060203https://doaj.org/article/bd83723b418445a08895948e1c17d2e22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23593173/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Tenomodulin (Tnmd) is a type II transmembrane protein characteristically expressed in dense connective tissues such as tendons and ligaments. Its expression in the periodontal ligament (PDL) has also been demonstrated, though the timing and function remain unclear. We investigated the expression of Tnmd during murine tooth eruption and explored its biological functions in vitro. Tnmd expression was related to the time of eruption when occlusal force was transferred to the teeth and surrounding tissues. Tnmd overexpression enhanced cell adhesion in NIH3T3 and human PDL cells. In addition, Tnmd-knockout fibroblasts showed decreased cell adhesion. In the extracellular portions of Tnmd, the BRICHOS domain or CS region was found to be responsible for Tnmd-mediated enhancement of cell adhesion. These results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain.Yuske KomiyamaShinsuke OhbaNobuyuki ShimohataKeiji NakajimaHironori HojoFumiko YanoTsuyoshi TakatoDenitsa DochevaChisa ShukunamiYuji HirakiUng-Il ChungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60203 (2013) |
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| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yuske Komiyama Shinsuke Ohba Nobuyuki Shimohata Keiji Nakajima Hironori Hojo Fumiko Yano Tsuyoshi Takato Denitsa Docheva Chisa Shukunami Yuji Hiraki Ung-Il Chung Tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| description |
Tenomodulin (Tnmd) is a type II transmembrane protein characteristically expressed in dense connective tissues such as tendons and ligaments. Its expression in the periodontal ligament (PDL) has also been demonstrated, though the timing and function remain unclear. We investigated the expression of Tnmd during murine tooth eruption and explored its biological functions in vitro. Tnmd expression was related to the time of eruption when occlusal force was transferred to the teeth and surrounding tissues. Tnmd overexpression enhanced cell adhesion in NIH3T3 and human PDL cells. In addition, Tnmd-knockout fibroblasts showed decreased cell adhesion. In the extracellular portions of Tnmd, the BRICHOS domain or CS region was found to be responsible for Tnmd-mediated enhancement of cell adhesion. These results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain. |
| format |
article |
| author |
Yuske Komiyama Shinsuke Ohba Nobuyuki Shimohata Keiji Nakajima Hironori Hojo Fumiko Yano Tsuyoshi Takato Denitsa Docheva Chisa Shukunami Yuji Hiraki Ung-Il Chung |
| author_facet |
Yuske Komiyama Shinsuke Ohba Nobuyuki Shimohata Keiji Nakajima Hironori Hojo Fumiko Yano Tsuyoshi Takato Denitsa Docheva Chisa Shukunami Yuji Hiraki Ung-Il Chung |
| author_sort |
Yuske Komiyama |
| title |
Tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| title_short |
Tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| title_full |
Tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| title_fullStr |
Tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| title_full_unstemmed |
Tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| title_sort |
tenomodulin expression in the periodontal ligament enhances cellular adhesion. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/bd83723b418445a08895948e1c17d2e2 |
| work_keys_str_mv |
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