Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface

Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few...

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Autores principales:	Iván P. Uray, Karen Uray
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mechanotransduction plasma membrane cytoskeleton cancer gastrointestinal Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bd842f0fc5af426e9a83b1b21b1073eb
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spelling	oai:doaj.org-article:bd842f0fc5af426e9a83b1b21b1073eb2021-11-11T17:03:01ZMechanotransduction at the Plasma Membrane-Cytoskeleton Interface10.3390/ijms2221115661422-00671661-6596https://doaj.org/article/bd842f0fc5af426e9a83b1b21b1073eb2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11566https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few decades, the role of mechanotransduction in physiological and pathological processes has been largely overlooked until recently. In this review, the role of interactions between the cytoskeleton and cell-cell/cell-matrix adhesions in transducing mechanical signals is discussed. In addition, mechanosensors that reside in the cell membrane and the transduction of mechanical signals to the nucleus are discussed. Finally, we describe two examples in which mechanotransduction plays a significant role in normal physiology and disease development. The first example is the role of mechanotransduction in the proliferation and metastasis of cancerous cells. In this system, the role of mechanotransduction in cellular processes, including proliferation, differentiation, and motility, is described. In the second example, the role of mechanotransduction in a mechanically active organ, the gastrointestinal tract, is described. In the gut, mechanotransduction contributes to normal physiology and the development of motility disorders.Iván P. UrayKaren UrayMDPI AGarticlemechanotransductionplasma membranecytoskeletoncancergastrointestinalBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11566, p 11566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mechanotransduction plasma membrane cytoskeleton cancer gastrointestinal Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mechanotransduction plasma membrane cytoskeleton cancer gastrointestinal Biology (General) QH301-705.5 Chemistry QD1-999 Iván P. Uray Karen Uray Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
description	Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few decades, the role of mechanotransduction in physiological and pathological processes has been largely overlooked until recently. In this review, the role of interactions between the cytoskeleton and cell-cell/cell-matrix adhesions in transducing mechanical signals is discussed. In addition, mechanosensors that reside in the cell membrane and the transduction of mechanical signals to the nucleus are discussed. Finally, we describe two examples in which mechanotransduction plays a significant role in normal physiology and disease development. The first example is the role of mechanotransduction in the proliferation and metastasis of cancerous cells. In this system, the role of mechanotransduction in cellular processes, including proliferation, differentiation, and motility, is described. In the second example, the role of mechanotransduction in a mechanically active organ, the gastrointestinal tract, is described. In the gut, mechanotransduction contributes to normal physiology and the development of motility disorders.
format	article
author	Iván P. Uray Karen Uray
author_facet	Iván P. Uray Karen Uray
author_sort	Iván P. Uray
title	Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_short	Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_full	Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_fullStr	Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_full_unstemmed	Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_sort	mechanotransduction at the plasma membrane-cytoskeleton interface
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bd842f0fc5af426e9a83b1b21b1073eb
work_keys_str_mv	AT ivanpuray mechanotransductionattheplasmamembranecytoskeletoninterface AT karenuray mechanotransductionattheplasmamembranecytoskeletoninterface
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Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface

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