Persistence of functional microbiota composition across generations

Abstract Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The “it’s the song, not the singer” theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserv...

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Autores principales:	Christian Ramos, Mario Calus, Dirkjan Schokker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd8bded1803c49bc8b7c01afbbc21720
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id	oai:doaj.org-article:bd8bded1803c49bc8b7c01afbbc21720
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spelling	oai:doaj.org-article:bd8bded1803c49bc8b7c01afbbc217202021-12-02T15:14:37ZPersistence of functional microbiota composition across generations10.1038/s41598-021-98097-32045-2322https://doaj.org/article/bd8bded1803c49bc8b7c01afbbc217202021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98097-3https://doaj.org/toc/2045-2322Abstract Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The “it’s the song, not the singer” theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserved across generations if interspecies interaction patterns perpetuate themselves. We tested conservation of functional composition across generations using zooplankton, mosquito, and plant datasets. Then, we tested if there is a change of functional microbiota composition over time within a generation in human datasets. Finally, we simulated microbiota communities to investigate if (pairwise) interactions can lead to multiple stable community compositions. Our results suggest that the vertically transmitted microbiota starts a predictable change of functions performed by the microbiota over time, whose robustness depends on the arrival of diverse migrants. This succession culminates in a stable functional composition state. The results suggest that the host-microbiota interaction and higher order interactions in general have an important contribution to the robustness of the final community. If the proposed mechanism proves to be valid for a diverse array of host species, this would support the concept of holobionts being used as units of selection, including animal breeding, suggesting this has a wider applicability.Christian RamosMario CalusDirkjan SchokkerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Ramos Mario Calus Dirkjan Schokker Persistence of functional microbiota composition across generations
description	Abstract Holobionts are defined as a host and its microbiota, however, only a fraction of the bacteria are inherited vertically and thus coevolve with the host. The “it’s the song, not the singer” theory proposes that functional traits, instead of taxonomical microbiota composition, could be preserved across generations if interspecies interaction patterns perpetuate themselves. We tested conservation of functional composition across generations using zooplankton, mosquito, and plant datasets. Then, we tested if there is a change of functional microbiota composition over time within a generation in human datasets. Finally, we simulated microbiota communities to investigate if (pairwise) interactions can lead to multiple stable community compositions. Our results suggest that the vertically transmitted microbiota starts a predictable change of functions performed by the microbiota over time, whose robustness depends on the arrival of diverse migrants. This succession culminates in a stable functional composition state. The results suggest that the host-microbiota interaction and higher order interactions in general have an important contribution to the robustness of the final community. If the proposed mechanism proves to be valid for a diverse array of host species, this would support the concept of holobionts being used as units of selection, including animal breeding, suggesting this has a wider applicability.
format	article
author	Christian Ramos Mario Calus Dirkjan Schokker
author_facet	Christian Ramos Mario Calus Dirkjan Schokker
author_sort	Christian Ramos
title	Persistence of functional microbiota composition across generations
title_short	Persistence of functional microbiota composition across generations
title_full	Persistence of functional microbiota composition across generations
title_fullStr	Persistence of functional microbiota composition across generations
title_full_unstemmed	Persistence of functional microbiota composition across generations
title_sort	persistence of functional microbiota composition across generations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd8bded1803c49bc8b7c01afbbc21720
work_keys_str_mv	AT christianramos persistenceoffunctionalmicrobiotacompositionacrossgenerations AT mariocalus persistenceoffunctionalmicrobiotacompositionacrossgenerations AT dirkjanschokker persistenceoffunctionalmicrobiotacompositionacrossgenerations
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Persistence of functional microbiota composition across generations

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