Eye movements in patients in early psychosis with and without a history of cannabis use

Abstract It is unclear whether early psychosis in the context of cannabis use is different from psychosis without cannabis. We investigated this issue by examining whether abnormalities in oculomotor control differ between patients with psychosis with and without a history of cannabis use. We studie...

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Autores principales:	Musa Basseer Sami, Luciano Annibale, Aisling O’Neill, Tracy Collier, Chidimma Onyejiaka, Savitha Eranti, Debasis Das, Marlene Kelbrick, Philip McGuire, Steve C. R. Williams, Anas Rana, Ulrich Ettinger, Sagnik Bhattacharyya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/bd8c75e77ed9487790dabd2f230b01e1
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spelling	oai:doaj.org-article:bd8c75e77ed9487790dabd2f230b01e12021-12-02T17:15:35ZEye movements in patients in early psychosis with and without a history of cannabis use10.1038/s41537-021-00155-22334-265Xhttps://doaj.org/article/bd8c75e77ed9487790dabd2f230b01e12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00155-2https://doaj.org/toc/2334-265XAbstract It is unclear whether early psychosis in the context of cannabis use is different from psychosis without cannabis. We investigated this issue by examining whether abnormalities in oculomotor control differ between patients with psychosis with and without a history of cannabis use. We studied four groups: patients in the early phase of psychosis with a history of cannabis use (EPC; n = 28); patients in the early phase of psychosis without (EPNC; n = 25); controls with a history of cannabis use (HCC; n = 16); and controls without (HCNC; n = 22). We studied smooth pursuit eye movements using a stimulus with sinusoidal waveform at three target frequencies (0.2, 0.4 and 0.6 Hz). Participants also performed 40 antisaccade trials. There were no differences between the EPC and EPNC groups in diagnosis, symptom severity or level of functioning. We found evidence for a cannabis effect (χ 2 = 23.14, p < 0.001), patient effect (χ 2 = 4.84, p = 0.028) and patient × cannabis effect (χ 2 = 4.20, p = 0.04) for smooth pursuit velocity gain. There was a large difference between EPC and EPNC (g = 0.76–0.86) with impairment in the non cannabis using group. We found no significant effect for antisaccade error whereas patients had fewer valid trials compared to controls. These data indicate that impairment of smooth pursuit in psychosis is more severe in patients without a history of cannabis use. This is consistent with the notion that the severity of neurobiological alterations in psychosis is lower in patients whose illness developed in the context of cannabis use.Musa Basseer SamiLuciano AnnibaleAisling O’NeillTracy CollierChidimma OnyejiakaSavitha ErantiDebasis DasMarlene KelbrickPhilip McGuireSteve C. R. WilliamsAnas RanaUlrich EttingerSagnik BhattacharyyaNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Musa Basseer Sami Luciano Annibale Aisling O’Neill Tracy Collier Chidimma Onyejiaka Savitha Eranti Debasis Das Marlene Kelbrick Philip McGuire Steve C. R. Williams Anas Rana Ulrich Ettinger Sagnik Bhattacharyya Eye movements in patients in early psychosis with and without a history of cannabis use
description	Abstract It is unclear whether early psychosis in the context of cannabis use is different from psychosis without cannabis. We investigated this issue by examining whether abnormalities in oculomotor control differ between patients with psychosis with and without a history of cannabis use. We studied four groups: patients in the early phase of psychosis with a history of cannabis use (EPC; n = 28); patients in the early phase of psychosis without (EPNC; n = 25); controls with a history of cannabis use (HCC; n = 16); and controls without (HCNC; n = 22). We studied smooth pursuit eye movements using a stimulus with sinusoidal waveform at three target frequencies (0.2, 0.4 and 0.6 Hz). Participants also performed 40 antisaccade trials. There were no differences between the EPC and EPNC groups in diagnosis, symptom severity or level of functioning. We found evidence for a cannabis effect (χ 2 = 23.14, p < 0.001), patient effect (χ 2 = 4.84, p = 0.028) and patient × cannabis effect (χ 2 = 4.20, p = 0.04) for smooth pursuit velocity gain. There was a large difference between EPC and EPNC (g = 0.76–0.86) with impairment in the non cannabis using group. We found no significant effect for antisaccade error whereas patients had fewer valid trials compared to controls. These data indicate that impairment of smooth pursuit in psychosis is more severe in patients without a history of cannabis use. This is consistent with the notion that the severity of neurobiological alterations in psychosis is lower in patients whose illness developed in the context of cannabis use.
format	article
author	Musa Basseer Sami Luciano Annibale Aisling O’Neill Tracy Collier Chidimma Onyejiaka Savitha Eranti Debasis Das Marlene Kelbrick Philip McGuire Steve C. R. Williams Anas Rana Ulrich Ettinger Sagnik Bhattacharyya
author_facet	Musa Basseer Sami Luciano Annibale Aisling O’Neill Tracy Collier Chidimma Onyejiaka Savitha Eranti Debasis Das Marlene Kelbrick Philip McGuire Steve C. R. Williams Anas Rana Ulrich Ettinger Sagnik Bhattacharyya
author_sort	Musa Basseer Sami
title	Eye movements in patients in early psychosis with and without a history of cannabis use
title_short	Eye movements in patients in early psychosis with and without a history of cannabis use
title_full	Eye movements in patients in early psychosis with and without a history of cannabis use
title_fullStr	Eye movements in patients in early psychosis with and without a history of cannabis use
title_full_unstemmed	Eye movements in patients in early psychosis with and without a history of cannabis use
title_sort	eye movements in patients in early psychosis with and without a history of cannabis use
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd8c75e77ed9487790dabd2f230b01e1
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Eye movements in patients in early psychosis with and without a history of cannabis use

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