The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

Koray Gumus1, Dwight H Cavanagh21Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey; 2Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USAPurpose: To review and integrate recent advances in identifying the role of infla...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koray Gumus, Dwight H Cavanagh
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bd92114979c3481aad1da6db9c5a1237
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bd92114979c3481aad1da6db9c5a1237
record_format	dspace
spelling	oai:doaj.org-article:bd92114979c3481aad1da6db9c5a12372021-12-02T01:39:53ZThe role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca1177-54671177-5483https://doaj.org/article/bd92114979c3481aad1da6db9c5a12372008-10-01T00:00:00Zhttp://www.dovepress.com/the-role-of-inflammation-and-antiinflammation-therapies-in-keratoconju-a2403https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Koray Gumus1, Dwight H Cavanagh21Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey; 2Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USAPurpose: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories.Methods: A comprehensive literature survey. Results and conclusion: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex&nbsp;disorder in which ocular surface infl ammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume&nbsp;with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.Keywords: dry eye, keratoconjunctivitis sicca, antiinflammatory therapy Koray GumusDwight H CavanaghDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 57-67 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Koray Gumus Dwight H Cavanagh The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
description	Koray Gumus1, Dwight H Cavanagh21Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey; 2Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, USAPurpose: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories.Methods: A comprehensive literature survey. Results and conclusion: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex&nbsp;disorder in which ocular surface infl ammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume&nbsp;with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.Keywords: dry eye, keratoconjunctivitis sicca, antiinflammatory therapy
format	article
author	Koray Gumus Dwight H Cavanagh
author_facet	Koray Gumus Dwight H Cavanagh
author_sort	Koray Gumus
title	The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_short	The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_full	The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_fullStr	The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_full_unstemmed	The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
title_sort	role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/bd92114979c3481aad1da6db9c5a1237
work_keys_str_mv	AT koraygumus theroleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca AT dwighthcavanagh theroleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca AT koraygumus roleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca AT dwighthcavanagh roleofinflammationandantiinflammationtherapiesinkeratoconjunctivitissicca
_version_	1718402982069927936

The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

Ejemplares similares