HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease

Abstract Huntington’s disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high thro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ravi Kiran Reddy Kalathur, José Pedro Pinto, Biswanath Sahoo, Gautam Chaurasia, Matthias E. Futschik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bd954ba1648f4ed8a28824086a5c3375
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bd954ba1648f4ed8a28824086a5c3375
record_format	dspace
spelling	oai:doaj.org-article:bd954ba1648f4ed8a28824086a5c33752021-12-02T15:05:42ZHDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease10.1038/s41598-017-05224-02045-2322https://doaj.org/article/bd954ba1648f4ed8a28824086a5c33752017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05224-0https://doaj.org/toc/2045-2322Abstract Huntington’s disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as microarrays and mass-spectrometry has indicated multiple pathogenic routes. The massive data generated by these techniques together with the complexity of the pathogenesis, however, pose considerable challenges to researchers. Network-based methods can provide valuable tools to consolidate newly generated data with existing knowledge, and to decipher the interwoven molecular mechanisms underlying HD. To facilitate research on HD in a network-oriented manner, we have developed HDNetDB, a database that integrates molecular interactions with many HD-relevant datasets. It allows users to obtain, visualize and prioritize molecular interaction networks using HD-relevant gene expression, phenotypic and other types of data obtained from human samples or model organisms. We illustrated several HDNetDB functionalities through a case study and identified proteins that constitute potential cross-talk between HD and the unfolded protein response (UPR). HDNetDB is publicly accessible at http://hdnetdb.sysbiolab.eu .Ravi Kiran Reddy KalathurJosé Pedro PintoBiswanath SahooGautam ChaurasiaMatthias E. FutschikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ravi Kiran Reddy Kalathur José Pedro Pinto Biswanath Sahoo Gautam Chaurasia Matthias E. Futschik HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease
description	Abstract Huntington’s disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as microarrays and mass-spectrometry has indicated multiple pathogenic routes. The massive data generated by these techniques together with the complexity of the pathogenesis, however, pose considerable challenges to researchers. Network-based methods can provide valuable tools to consolidate newly generated data with existing knowledge, and to decipher the interwoven molecular mechanisms underlying HD. To facilitate research on HD in a network-oriented manner, we have developed HDNetDB, a database that integrates molecular interactions with many HD-relevant datasets. It allows users to obtain, visualize and prioritize molecular interaction networks using HD-relevant gene expression, phenotypic and other types of data obtained from human samples or model organisms. We illustrated several HDNetDB functionalities through a case study and identified proteins that constitute potential cross-talk between HD and the unfolded protein response (UPR). HDNetDB is publicly accessible at http://hdnetdb.sysbiolab.eu .
format	article
author	Ravi Kiran Reddy Kalathur José Pedro Pinto Biswanath Sahoo Gautam Chaurasia Matthias E. Futschik
author_facet	Ravi Kiran Reddy Kalathur José Pedro Pinto Biswanath Sahoo Gautam Chaurasia Matthias E. Futschik
author_sort	Ravi Kiran Reddy Kalathur
title	HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease
title_short	HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease
title_full	HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease
title_fullStr	HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease
title_full_unstemmed	HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease
title_sort	hdnetdb: a molecular interaction database for network-oriented investigations into huntington’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bd954ba1648f4ed8a28824086a5c3375
work_keys_str_mv	AT ravikiranreddykalathur hdnetdbamolecularinteractiondatabasefornetworkorientedinvestigationsintohuntingtonsdisease AT josepedropinto hdnetdbamolecularinteractiondatabasefornetworkorientedinvestigationsintohuntingtonsdisease AT biswanathsahoo hdnetdbamolecularinteractiondatabasefornetworkorientedinvestigationsintohuntingtonsdisease AT gautamchaurasia hdnetdbamolecularinteractiondatabasefornetworkorientedinvestigationsintohuntingtonsdisease AT matthiasefutschik hdnetdbamolecularinteractiondatabasefornetworkorientedinvestigationsintohuntingtonsdisease
_version_	1718388729612075008

HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease

Ejemplares similares