Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications

The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical pr...

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Autores principales:	Atanu Naskar, Hyejin Cho, Sohee Lee, Kwang-sun Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bacterial outer membrane vesicles (OMVs) membrane coating biomimetic nanoparticles biomedical applications Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/bd9a698276d647238ddb0c5e154a7227
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spelling	oai:doaj.org-article:bd9a698276d647238ddb0c5e154a72272021-11-25T18:41:29ZBiomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications10.3390/pharmaceutics131118871999-4923https://doaj.org/article/bd9a698276d647238ddb0c5e154a72272021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1887https://doaj.org/toc/1999-4923The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical properties of synthetic nanoparticles but also the original biological functions of the cellular materials. Accordingly, NPs coated with cell-derived membrane components have achieved remarkable growth as prospective biomedical materials. Particularly, bacterial outer membrane vesicle (OMV), which is a cell membrane coating material for NPs, is regarded as an important molecule that can be employed in several biomedical applications, including immune response activation, cancer therapeutics, and treatment for bacterial infections with photothermal activity. The currently available cell membrane-coated NPs are summarized in this review. Furthermore, the general features of bacterial OMVs and several multifunctional NPs that could serve as inner core materials in the coating strategy are presented, and several methods that can be used to prepare OMV-coated NPs (OMV-NPs) and their characterization are highlighted. Finally, some perspectives of OMV-NPs in various biomedical applications for future potential breakthrough are discussed. This in-depth review, which includes potential challenges, will encourage researchers to fabricate innovative and improvised, new-generation biomimetic materials through future biomedical applications.Atanu NaskarHyejin ChoSohee LeeKwang-sun KimMDPI AGarticlebacterial outer membrane vesicles (OMVs)membrane coatingbiomimetic nanoparticlesbiomedical applicationsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1887, p 1887 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial outer membrane vesicles (OMVs) membrane coating biomimetic nanoparticles biomedical applications Pharmacy and materia medica RS1-441
spellingShingle	bacterial outer membrane vesicles (OMVs) membrane coating biomimetic nanoparticles biomedical applications Pharmacy and materia medica RS1-441 Atanu Naskar Hyejin Cho Sohee Lee Kwang-sun Kim Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
description	The biomedical field is currently reaping the benefits of research on biomimetic nanoparticles (NPs), which are synthetic nanoparticles fabricated with natural cellular materials for nature-inspired biomedical applications. These camouflage NPs are capable of retaining not only the physiochemical properties of synthetic nanoparticles but also the original biological functions of the cellular materials. Accordingly, NPs coated with cell-derived membrane components have achieved remarkable growth as prospective biomedical materials. Particularly, bacterial outer membrane vesicle (OMV), which is a cell membrane coating material for NPs, is regarded as an important molecule that can be employed in several biomedical applications, including immune response activation, cancer therapeutics, and treatment for bacterial infections with photothermal activity. The currently available cell membrane-coated NPs are summarized in this review. Furthermore, the general features of bacterial OMVs and several multifunctional NPs that could serve as inner core materials in the coating strategy are presented, and several methods that can be used to prepare OMV-coated NPs (OMV-NPs) and their characterization are highlighted. Finally, some perspectives of OMV-NPs in various biomedical applications for future potential breakthrough are discussed. This in-depth review, which includes potential challenges, will encourage researchers to fabricate innovative and improvised, new-generation biomimetic materials through future biomedical applications.
format	article
author	Atanu Naskar Hyejin Cho Sohee Lee Kwang-sun Kim
author_facet	Atanu Naskar Hyejin Cho Sohee Lee Kwang-sun Kim
author_sort	Atanu Naskar
title	Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_short	Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_full	Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_fullStr	Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_full_unstemmed	Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications
title_sort	biomimetic nanoparticles coated with bacterial outer membrane vesicles as a new-generation platform for biomedical applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bd9a698276d647238ddb0c5e154a7227
work_keys_str_mv	AT atanunaskar biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications AT hyejincho biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications AT soheelee biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications AT kwangsunkim biomimeticnanoparticlescoatedwithbacterialoutermembranevesiclesasanewgenerationplatformforbiomedicalapplications
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Biomimetic Nanoparticles Coated with Bacterial Outer Membrane Vesicles as a New-Generation Platform for Biomedical Applications

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