Site-specific incorporation of citrulline into proteins in mammalian cells

Citrullination of arginine is crucial for several physiological processes. Here the authors report the site-specific incorporation of citrulline into proteins in mammalian cells using an engineered tRNA synthetase/tRNA pair and a photocaged-citrulline.

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Autores principales:	Santanu Mondal, Shu Wang, Yunan Zheng, Sudeshna Sen, Abhishek Chatterjee, Paul R. Thompson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd9c1f5a80e24b4ca721bf1b4716c16e
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spelling	oai:doaj.org-article:bd9c1f5a80e24b4ca721bf1b4716c16e2021-12-02T15:08:01ZSite-specific incorporation of citrulline into proteins in mammalian cells10.1038/s41467-020-20279-w2041-1723https://doaj.org/article/bd9c1f5a80e24b4ca721bf1b4716c16e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20279-whttps://doaj.org/toc/2041-1723Citrullination of arginine is crucial for several physiological processes. Here the authors report the site-specific incorporation of citrulline into proteins in mammalian cells using an engineered tRNA synthetase/tRNA pair and a photocaged-citrulline.Santanu MondalShu WangYunan ZhengSudeshna SenAbhishek ChatterjeePaul R. ThompsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Santanu Mondal Shu Wang Yunan Zheng Sudeshna Sen Abhishek Chatterjee Paul R. Thompson Site-specific incorporation of citrulline into proteins in mammalian cells
description	Citrullination of arginine is crucial for several physiological processes. Here the authors report the site-specific incorporation of citrulline into proteins in mammalian cells using an engineered tRNA synthetase/tRNA pair and a photocaged-citrulline.
format	article
author	Santanu Mondal Shu Wang Yunan Zheng Sudeshna Sen Abhishek Chatterjee Paul R. Thompson
author_facet	Santanu Mondal Shu Wang Yunan Zheng Sudeshna Sen Abhishek Chatterjee Paul R. Thompson
author_sort	Santanu Mondal
title	Site-specific incorporation of citrulline into proteins in mammalian cells
title_short	Site-specific incorporation of citrulline into proteins in mammalian cells
title_full	Site-specific incorporation of citrulline into proteins in mammalian cells
title_fullStr	Site-specific incorporation of citrulline into proteins in mammalian cells
title_full_unstemmed	Site-specific incorporation of citrulline into proteins in mammalian cells
title_sort	site-specific incorporation of citrulline into proteins in mammalian cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bd9c1f5a80e24b4ca721bf1b4716c16e
work_keys_str_mv	AT santanumondal sitespecificincorporationofcitrullineintoproteinsinmammaliancells AT shuwang sitespecificincorporationofcitrullineintoproteinsinmammaliancells AT yunanzheng sitespecificincorporationofcitrullineintoproteinsinmammaliancells AT sudeshnasen sitespecificincorporationofcitrullineintoproteinsinmammaliancells AT abhishekchatterjee sitespecificincorporationofcitrullineintoproteinsinmammaliancells AT paulrthompson sitespecificincorporationofcitrullineintoproteinsinmammaliancells
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Site-specific incorporation of citrulline into proteins in mammalian cells

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