TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid

Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsid surface and initiate lattice growth.

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Autores principales:	Alvin Yu, Katarzyna A. Skorupka, Alexander J. Pak, Barbie K. Ganser-Pornillos, Owen Pornillos, Gregory A. Voth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bd9cc94b90814f36bcde658814d9e443
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spelling	oai:doaj.org-article:bd9cc94b90814f36bcde658814d9e4432021-12-02T13:35:01ZTRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid10.1038/s41467-020-15106-12041-1723https://doaj.org/article/bd9cc94b90814f36bcde658814d9e4432020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15106-1https://doaj.org/toc/2041-1723Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsid surface and initiate lattice growth.Alvin YuKatarzyna A. SkorupkaAlexander J. PakBarbie K. Ganser-PornillosOwen PornillosGregory A. VothNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alvin Yu Katarzyna A. Skorupka Alexander J. Pak Barbie K. Ganser-Pornillos Owen Pornillos Gregory A. Voth TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
description	Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsid surface and initiate lattice growth.
format	article
author	Alvin Yu Katarzyna A. Skorupka Alexander J. Pak Barbie K. Ganser-Pornillos Owen Pornillos Gregory A. Voth
author_facet	Alvin Yu Katarzyna A. Skorupka Alexander J. Pak Barbie K. Ganser-Pornillos Owen Pornillos Gregory A. Voth
author_sort	Alvin Yu
title	TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
title_short	TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
title_full	TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
title_fullStr	TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
title_full_unstemmed	TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
title_sort	trim5α self-assembly and compartmentalization of the hiv-1 viral capsid
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bd9cc94b90814f36bcde658814d9e443
work_keys_str_mv	AT alvinyu trim5aselfassemblyandcompartmentalizationofthehiv1viralcapsid AT katarzynaaskorupka trim5aselfassemblyandcompartmentalizationofthehiv1viralcapsid AT alexanderjpak trim5aselfassemblyandcompartmentalizationofthehiv1viralcapsid AT barbiekganserpornillos trim5aselfassemblyandcompartmentalizationofthehiv1viralcapsid AT owenpornillos trim5aselfassemblyandcompartmentalizationofthehiv1viralcapsid AT gregoryavoth trim5aselfassemblyandcompartmentalizationofthehiv1viralcapsid
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TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid

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