PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients...

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Autores principales:	Cristiano Sacchetti, Yunpeng Bai, Stephanie M. Stanford, Paola Di Benedetto, Paola Cipriani, Eugenio Santelli, Sonsoles Piera-Velazquez, Vladimir Chernitskiy, William B. Kiosses, Arnold Ceponis, Klaus H. Kaestner, Francesco Boin, Sergio A. Jimenez, Roberto Giacomelli, Zhong-Yin Zhang, Nunzio Bottini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bda2249f57354c398a9b7c97bc41a7fd
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spelling	oai:doaj.org-article:bda2249f57354c398a9b7c97bc41a7fd2021-12-02T14:42:01ZPTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis10.1038/s41467-017-01168-12041-1723https://doaj.org/article/bda2249f57354c398a9b7c97bc41a7fd2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01168-1https://doaj.org/toc/2041-1723Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients with systemic sclerosis and promotes TGFβ activity via SRC–ERK–SMAD3 signaling.Cristiano SacchettiYunpeng BaiStephanie M. StanfordPaola Di BenedettoPaola CiprianiEugenio SantelliSonsoles Piera-VelazquezVladimir ChernitskiyWilliam B. KiossesArnold CeponisKlaus H. KaestnerFrancesco BoinSergio A. JimenezRoberto GiacomelliZhong-Yin ZhangNunzio BottiniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristiano Sacchetti Yunpeng Bai Stephanie M. Stanford Paola Di Benedetto Paola Cipriani Eugenio Santelli Sonsoles Piera-Velazquez Vladimir Chernitskiy William B. Kiosses Arnold Ceponis Klaus H. Kaestner Francesco Boin Sergio A. Jimenez Roberto Giacomelli Zhong-Yin Zhang Nunzio Bottini PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
description	Although protein tyrosine kinases are being explored as antifibrotic agents for the treatment of systemic sclerosis, little is known about the function of counteractive protein tyrosine phosphatases in this context. Here, the authors show that PTP4A1 is highly expressed by fibroblasts from patients with systemic sclerosis and promotes TGFβ activity via SRC–ERK–SMAD3 signaling.
format	article
author	Cristiano Sacchetti Yunpeng Bai Stephanie M. Stanford Paola Di Benedetto Paola Cipriani Eugenio Santelli Sonsoles Piera-Velazquez Vladimir Chernitskiy William B. Kiosses Arnold Ceponis Klaus H. Kaestner Francesco Boin Sergio A. Jimenez Roberto Giacomelli Zhong-Yin Zhang Nunzio Bottini
author_facet	Cristiano Sacchetti Yunpeng Bai Stephanie M. Stanford Paola Di Benedetto Paola Cipriani Eugenio Santelli Sonsoles Piera-Velazquez Vladimir Chernitskiy William B. Kiosses Arnold Ceponis Klaus H. Kaestner Francesco Boin Sergio A. Jimenez Roberto Giacomelli Zhong-Yin Zhang Nunzio Bottini
author_sort	Cristiano Sacchetti
title	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_short	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_full	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_fullStr	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_full_unstemmed	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis
title_sort	ptp4a1 promotes tgfβ signaling and fibrosis in systemic sclerosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bda2249f57354c398a9b7c97bc41a7fd
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PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis

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