Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study

Abstract Background Muscle weakness and exercise intolerance contribute to reduced quality of life (QOL) in Barth syndrome (BTHS). Our group previously found that 12 weeks of resistance exercise training (RET) improved muscle strength, however, did not increase muscle (lean) mass or QOL in n = 3 you...

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Autores principales:	Kathryn L. Bohnert, Grace Ditzenberger, Adam J. Bittel, Lisa de lasFuentes, Manuela Corti, Christina A. Pacak, Carolyn Taylor, Barry J. Byrne, Dominic N. Reeds, W. Todd Cade
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	amino acid exercise muscle strength training Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/bda2cf0580534a32a6f3a6972555f1cf
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spelling	oai:doaj.org-article:bda2cf0580534a32a6f3a6972555f1cf2021-11-08T13:27:19ZResistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study2192-831210.1002/jmd2.12244https://doaj.org/article/bda2cf0580534a32a6f3a6972555f1cf2021-11-01T00:00:00Zhttps://doi.org/10.1002/jmd2.12244https://doaj.org/toc/2192-8312Abstract Background Muscle weakness and exercise intolerance contribute to reduced quality of life (QOL) in Barth syndrome (BTHS). Our group previously found that 12 weeks of resistance exercise training (RET) improved muscle strength, however, did not increase muscle (lean) mass or QOL in n = 3 young adults with BTHS. The overall objective of this pilot study was to examine the safety and effectiveness of RET plus daily protein supplementation (RET + protein) on muscle strength, skeletal muscle mass, exercise tolerance, cardiac function, and QOL in late adolescents/young adults with BTHS. Methods Participants with BTHS (n = 5, age 27 ± 7) performed 12 weeks of supervised RET (60 minutes per session, three sessions/week) and consumed 42 g/day of whey protein. Muscle strength, muscle mass, exercise capacity, cardiac function, and health‐related QOL were assessed pre‐post intervention. Results RET + protein was safe, increased muscle strength and quality of life, and tended to increase lean mass. Conclusions RET + protein appears safe, increases muscle strength and quality of life and tends to increase lean mass. Larger studies are needed to confirm these findings and to fully determine the effects of RET + protein in individuals with BTHS.Kathryn L. BohnertGrace DitzenbergerAdam J. BittelLisa de lasFuentesManuela CortiChristina A. PacakCarolyn TaylorBarry J. ByrneDominic N. ReedsW. Todd CadeWileyarticleamino acidexercisemusclestrength trainingDiseases of the endocrine glands. Clinical endocrinologyRC648-665GeneticsQH426-470ENJIMD Reports, Vol 62, Iss 1, Pp 74-84 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amino acid exercise muscle strength training Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470
spellingShingle	amino acid exercise muscle strength training Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470 Kathryn L. Bohnert Grace Ditzenberger Adam J. Bittel Lisa de lasFuentes Manuela Corti Christina A. Pacak Carolyn Taylor Barry J. Byrne Dominic N. Reeds W. Todd Cade Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study
description	Abstract Background Muscle weakness and exercise intolerance contribute to reduced quality of life (QOL) in Barth syndrome (BTHS). Our group previously found that 12 weeks of resistance exercise training (RET) improved muscle strength, however, did not increase muscle (lean) mass or QOL in n = 3 young adults with BTHS. The overall objective of this pilot study was to examine the safety and effectiveness of RET plus daily protein supplementation (RET + protein) on muscle strength, skeletal muscle mass, exercise tolerance, cardiac function, and QOL in late adolescents/young adults with BTHS. Methods Participants with BTHS (n = 5, age 27 ± 7) performed 12 weeks of supervised RET (60 minutes per session, three sessions/week) and consumed 42 g/day of whey protein. Muscle strength, muscle mass, exercise capacity, cardiac function, and health‐related QOL were assessed pre‐post intervention. Results RET + protein was safe, increased muscle strength and quality of life, and tended to increase lean mass. Conclusions RET + protein appears safe, increases muscle strength and quality of life and tends to increase lean mass. Larger studies are needed to confirm these findings and to fully determine the effects of RET + protein in individuals with BTHS.
format	article
author	Kathryn L. Bohnert Grace Ditzenberger Adam J. Bittel Lisa de lasFuentes Manuela Corti Christina A. Pacak Carolyn Taylor Barry J. Byrne Dominic N. Reeds W. Todd Cade
author_facet	Kathryn L. Bohnert Grace Ditzenberger Adam J. Bittel Lisa de lasFuentes Manuela Corti Christina A. Pacak Carolyn Taylor Barry J. Byrne Dominic N. Reeds W. Todd Cade
author_sort	Kathryn L. Bohnert
title	Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study
title_short	Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study
title_full	Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study
title_fullStr	Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study
title_full_unstemmed	Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study
title_sort	resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with barth syndrome: a pilot study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/bda2cf0580534a32a6f3a6972555f1cf
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Resistance exercise training with protein supplementation improves skeletal muscle strength and improves quality of life in late adolescents and young adults with Barth syndrome: A pilot study

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