Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?

It has been argued that the emergence of roughly periodic orientation preference maps (OPMs) in the primary visual cortex (V1) of carnivores and primates can be explained by a so-called statistical connectivity model. This model assumes that input to V1 neurons is dominated by feed-forward projectio...

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Autores principales:	Manuel Schottdorf, Stephen J Eglen, Fred Wolf, Wolfgang Keil
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bda4d4a122e643619da89d809b7bcd15
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spelling	oai:doaj.org-article:bda4d4a122e643619da89d809b7bcd152021-11-18T08:35:54ZCan retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?1932-620310.1371/journal.pone.0086139https://doaj.org/article/bda4d4a122e643619da89d809b7bcd152014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24475081/?tool=EBIhttps://doaj.org/toc/1932-6203It has been argued that the emergence of roughly periodic orientation preference maps (OPMs) in the primary visual cortex (V1) of carnivores and primates can be explained by a so-called statistical connectivity model. This model assumes that input to V1 neurons is dominated by feed-forward projections originating from a small set of retinal ganglion cells (RGCs). The typical spacing between adjacent cortical orientation columns preferring the same orientation then arises via Moiré-Interference between hexagonal ON/OFF RGC mosaics. While this Moiré-Interference critically depends on long-range hexagonal order within the RGC mosaics, a recent statistical analysis of RGC receptive field positions found no evidence for such long-range positional order. Hexagonal order may be only one of several ways to obtain spatially repetitive OPMs in the statistical connectivity model. Here, we investigate a more general requirement on the spatial structure of RGC mosaics that can seed the emergence of spatially repetitive cortical OPMs, namely that angular correlations between so-called RGC dipoles exhibit a spatial structure similar to that of OPM autocorrelation functions. Both in cat beta cell mosaics as well as primate parasol receptive field mosaics we find that RGC dipole angles are spatially uncorrelated. To help assess the level of these correlations, we introduce a novel point process that generates mosaics with realistic nearest neighbor statistics and a tunable degree of spatial correlations of dipole angles. Using this process, we show that given the size of available data sets, the presence of even weak angular correlations in the data is very unlikely. We conclude that the layout of ON/OFF ganglion cell mosaics lacks the spatial structure necessary to seed iso-orientation domains in the primary visual cortex.Manuel SchottdorfStephen J EglenFred WolfWolfgang KeilPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86139 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manuel Schottdorf Stephen J Eglen Fred Wolf Wolfgang Keil Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
description	It has been argued that the emergence of roughly periodic orientation preference maps (OPMs) in the primary visual cortex (V1) of carnivores and primates can be explained by a so-called statistical connectivity model. This model assumes that input to V1 neurons is dominated by feed-forward projections originating from a small set of retinal ganglion cells (RGCs). The typical spacing between adjacent cortical orientation columns preferring the same orientation then arises via Moiré-Interference between hexagonal ON/OFF RGC mosaics. While this Moiré-Interference critically depends on long-range hexagonal order within the RGC mosaics, a recent statistical analysis of RGC receptive field positions found no evidence for such long-range positional order. Hexagonal order may be only one of several ways to obtain spatially repetitive OPMs in the statistical connectivity model. Here, we investigate a more general requirement on the spatial structure of RGC mosaics that can seed the emergence of spatially repetitive cortical OPMs, namely that angular correlations between so-called RGC dipoles exhibit a spatial structure similar to that of OPM autocorrelation functions. Both in cat beta cell mosaics as well as primate parasol receptive field mosaics we find that RGC dipole angles are spatially uncorrelated. To help assess the level of these correlations, we introduce a novel point process that generates mosaics with realistic nearest neighbor statistics and a tunable degree of spatial correlations of dipole angles. Using this process, we show that given the size of available data sets, the presence of even weak angular correlations in the data is very unlikely. We conclude that the layout of ON/OFF ganglion cell mosaics lacks the spatial structure necessary to seed iso-orientation domains in the primary visual cortex.
format	article
author	Manuel Schottdorf Stephen J Eglen Fred Wolf Wolfgang Keil
author_facet	Manuel Schottdorf Stephen J Eglen Fred Wolf Wolfgang Keil
author_sort	Manuel Schottdorf
title	Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
title_short	Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
title_full	Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
title_fullStr	Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
title_full_unstemmed	Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
title_sort	can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/bda4d4a122e643619da89d809b7bcd15
work_keys_str_mv	AT manuelschottdorf canretinalganglioncelldipolesseedisoorientationdomainsinthevisualcortex AT stephenjeglen canretinalganglioncelldipolesseedisoorientationdomainsinthevisualcortex AT fredwolf canretinalganglioncelldipolesseedisoorientationdomainsinthevisualcortex AT wolfgangkeil canretinalganglioncelldipolesseedisoorientationdomainsinthevisualcortex
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Can retinal ganglion cell dipoles seed iso-orientation domains in the visual cortex?

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