Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma
Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.
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Nature Portfolio
2019
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oai:doaj.org-article:bda58627bc774fe381635dc078c376162021-12-02T16:57:12ZTumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma10.1038/s41467-019-10493-62041-1723https://doaj.org/article/bda58627bc774fe381635dc078c376162019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10493-6https://doaj.org/toc/2041-1723Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.Dieter Henrik HeilandVidhya M. RaviSimon P. BehringerJan Hendrik FrenkingJulian WurmKevin JosephNicklas W. C. GarrelfsJakob SträhleSabrina HeynckesJürgen GrauvogelPamela FrancoIrina MaderMatthias SchneiderAnna-Laura PotthoffDaniel DelevUlrich G. HofmannChristian FungJürgen BeckRoman SankowskiMarco PrinzOliver SchnellNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dieter Henrik Heiland Vidhya M. Ravi Simon P. Behringer Jan Hendrik Frenking Julian Wurm Kevin Joseph Nicklas W. C. Garrelfs Jakob Strähle Sabrina Heynckes Jürgen Grauvogel Pamela Franco Irina Mader Matthias Schneider Anna-Laura Potthoff Daniel Delev Ulrich G. Hofmann Christian Fung Jürgen Beck Roman Sankowski Marco Prinz Oliver Schnell Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| description |
Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model. |
| format |
article |
| author |
Dieter Henrik Heiland Vidhya M. Ravi Simon P. Behringer Jan Hendrik Frenking Julian Wurm Kevin Joseph Nicklas W. C. Garrelfs Jakob Strähle Sabrina Heynckes Jürgen Grauvogel Pamela Franco Irina Mader Matthias Schneider Anna-Laura Potthoff Daniel Delev Ulrich G. Hofmann Christian Fung Jürgen Beck Roman Sankowski Marco Prinz Oliver Schnell |
| author_facet |
Dieter Henrik Heiland Vidhya M. Ravi Simon P. Behringer Jan Hendrik Frenking Julian Wurm Kevin Joseph Nicklas W. C. Garrelfs Jakob Strähle Sabrina Heynckes Jürgen Grauvogel Pamela Franco Irina Mader Matthias Schneider Anna-Laura Potthoff Daniel Delev Ulrich G. Hofmann Christian Fung Jürgen Beck Roman Sankowski Marco Prinz Oliver Schnell |
| author_sort |
Dieter Henrik Heiland |
| title |
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_short |
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_full |
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_fullStr |
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_full_unstemmed |
Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_sort |
tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/bda58627bc774fe381635dc078c37616 |
| work_keys_str_mv |
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| _version_ |
1718382587613806592 |