CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS

A sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous hum...

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Autores principales:	A. V. Klimovich, M. T. Van Lint, M. P. Samoilovich, B. V. Afanasiev, V. B. Klimovich
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	igg subclasses allogeneic bone marrow early posttransplant period immunoglobulins catabolism Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bda7c23e97b142d88f698a8f85a1d7b7
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spelling	oai:doaj.org-article:bda7c23e97b142d88f698a8f85a1d7b72021-11-18T08:03:37ZCONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS1563-06252313-741X10.15789/1563-0625-2009-1-41-48https://doaj.org/article/bda7c23e97b142d88f698a8f85a1d7b72014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/94https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous human immunoglobulins in allo-BM-recipients. In present study, multiple repeated measurements of different IgG subclasses were performed in blood serum of thirty-six patients at early terms after allogenic bone marrow transplantation period, along with analysis of individual clinical data. The study revealed several factors that show significant associations with IgG levels posttransplant. Moderate decrease in concentrations of IgG subclasses was registered after conditioning treatment carried out before the transplantation. Significantly decreased concentrations of IgG subclasses have been revealed during bleedings, diarrhea and glucocorticosteroid therapy. In general, however, no regular prolonged deficiency for total IgG subclasses was found in allogeneic bone marrow recipients during early posttransplant period.A. V. KlimovichM. T. Van LintM. P. SamoilovichB. V. AfanasievV. B. KlimovichSPb RAACIarticleigg subclassesallogeneic bone marrowearly posttransplant periodimmunoglobulins catabolismImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 41-48 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	igg subclasses allogeneic bone marrow early posttransplant period immunoglobulins catabolism Immunologic diseases. Allergy RC581-607
spellingShingle	igg subclasses allogeneic bone marrow early posttransplant period immunoglobulins catabolism Immunologic diseases. Allergy RC581-607 A. V. Klimovich M. T. Van Lint M. P. Samoilovich B. V. Afanasiev V. B. Klimovich CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
description	A sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients. That was the main reason for therapeutic application of intravenous human immunoglobulins in allo-BM-recipients. In present study, multiple repeated measurements of different IgG subclasses were performed in blood serum of thirty-six patients at early terms after allogenic bone marrow transplantation period, along with analysis of individual clinical data. The study revealed several factors that show significant associations with IgG levels posttransplant. Moderate decrease in concentrations of IgG subclasses was registered after conditioning treatment carried out before the transplantation. Significantly decreased concentrations of IgG subclasses have been revealed during bleedings, diarrhea and glucocorticosteroid therapy. In general, however, no regular prolonged deficiency for total IgG subclasses was found in allogeneic bone marrow recipients during early posttransplant period.
format	article
author	A. V. Klimovich M. T. Van Lint M. P. Samoilovich B. V. Afanasiev V. B. Klimovich
author_facet	A. V. Klimovich M. T. Van Lint M. P. Samoilovich B. V. Afanasiev V. B. Klimovich
author_sort	A. V. Klimovich
title	CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
title_short	CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
title_full	CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
title_fullStr	CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
title_full_unstemmed	CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS
title_sort	concentrations of igg subclasses in allogeneic bone marrow recipients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bda7c23e97b142d88f698a8f85a1d7b7
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CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS

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