Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on resi...

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Autores principales:	Jong-Ho Lee, Rui Liu, Jing Li, Chuanbao Zhang, Yugang Wang, Qingsong Cai, Xu Qian, Yan Xia, Yanhua Zheng, Yuji Piao, Qianming Chen, John F. de Groot, Tao Jiang, Zhimin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bda913409b324c509ae124cfd1dbb096
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spelling	oai:doaj.org-article:bda913409b324c509ae124cfd1dbb0962021-12-02T14:42:42ZStabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis10.1038/s41467-017-00906-92041-1723https://doaj.org/article/bda913409b324c509ae124cfd1dbb0962017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00906-9https://doaj.org/toc/2041-1723Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386.Jong-Ho LeeRui LiuJing LiChuanbao ZhangYugang WangQingsong CaiXu QianYan XiaYanhua ZhengYuji PiaoQianming ChenJohn F. de GrootTao JiangZhimin LuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jong-Ho Lee Rui Liu Jing Li Chuanbao Zhang Yugang Wang Qingsong Cai Xu Qian Yan Xia Yanhua Zheng Yuji Piao Qianming Chen John F. de Groot Tao Jiang Zhimin Lu Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
description	Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386.
format	article
author	Jong-Ho Lee Rui Liu Jing Li Chuanbao Zhang Yugang Wang Qingsong Cai Xu Qian Yan Xia Yanhua Zheng Yuji Piao Qianming Chen John F. de Groot Tao Jiang Zhimin Lu
author_facet	Jong-Ho Lee Rui Liu Jing Li Chuanbao Zhang Yugang Wang Qingsong Cai Xu Qian Yan Xia Yanhua Zheng Yuji Piao Qianming Chen John F. de Groot Tao Jiang Zhimin Lu
author_sort	Jong-Ho Lee
title	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
title_short	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
title_full	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
title_fullStr	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
title_full_unstemmed	Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
title_sort	stabilization of phosphofructokinase 1 platelet isoform by akt promotes tumorigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bda913409b324c509ae124cfd1dbb096
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Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

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