Ambient noise exposure induces long-term adaptations in adult brainstem neurons

Abstract To counterbalance long-term environmental changes, neuronal circuits adapt the processing of sensory information. In the auditory system, ongoing background noise drives long-lasting adaptive mechanism in binaural coincidence detector neurons in the superior olive. However, the compensatory...

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Autores principales:	Ida Siveke, Mike H. Myoga, Benedikt Grothe, Felix Felmy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bda93caa9625422ca5ef9d02ad1e8c61
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spelling	oai:doaj.org-article:bda93caa9625422ca5ef9d02ad1e8c612021-12-02T11:35:41ZAmbient noise exposure induces long-term adaptations in adult brainstem neurons10.1038/s41598-021-84230-92045-2322https://doaj.org/article/bda93caa9625422ca5ef9d02ad1e8c612021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84230-9https://doaj.org/toc/2045-2322Abstract To counterbalance long-term environmental changes, neuronal circuits adapt the processing of sensory information. In the auditory system, ongoing background noise drives long-lasting adaptive mechanism in binaural coincidence detector neurons in the superior olive. However, the compensatory cellular mechanisms of the binaural neurons in the medial superior olive (MSO) to long-term background changes are unexplored. Here we investigated the cellular properties of MSO neurons during long-lasting adaptations induced by moderate omnidirectional noise exposure. After noise exposure, the input resistance of MSO neurons of mature Mongolian gerbils was reduced, likely due to an upregulation of hyperpolarisation-activated cation and low voltage-activated potassium currents. Functionally, the long-lasting adaptations increased the action potential current threshold and facilitated high frequency output generation. Noise exposure accelerated the occurrence of spontaneous postsynaptic currents. Together, our data suggest that cellular adaptations in coincidence detector neurons of the MSO to continuous noise exposure likely increase the sensitivity to differences in sound pressure levels.Ida SivekeMike H. MyogaBenedikt GrotheFelix FelmyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ida Siveke Mike H. Myoga Benedikt Grothe Felix Felmy Ambient noise exposure induces long-term adaptations in adult brainstem neurons
description	Abstract To counterbalance long-term environmental changes, neuronal circuits adapt the processing of sensory information. In the auditory system, ongoing background noise drives long-lasting adaptive mechanism in binaural coincidence detector neurons in the superior olive. However, the compensatory cellular mechanisms of the binaural neurons in the medial superior olive (MSO) to long-term background changes are unexplored. Here we investigated the cellular properties of MSO neurons during long-lasting adaptations induced by moderate omnidirectional noise exposure. After noise exposure, the input resistance of MSO neurons of mature Mongolian gerbils was reduced, likely due to an upregulation of hyperpolarisation-activated cation and low voltage-activated potassium currents. Functionally, the long-lasting adaptations increased the action potential current threshold and facilitated high frequency output generation. Noise exposure accelerated the occurrence of spontaneous postsynaptic currents. Together, our data suggest that cellular adaptations in coincidence detector neurons of the MSO to continuous noise exposure likely increase the sensitivity to differences in sound pressure levels.
format	article
author	Ida Siveke Mike H. Myoga Benedikt Grothe Felix Felmy
author_facet	Ida Siveke Mike H. Myoga Benedikt Grothe Felix Felmy
author_sort	Ida Siveke
title	Ambient noise exposure induces long-term adaptations in adult brainstem neurons
title_short	Ambient noise exposure induces long-term adaptations in adult brainstem neurons
title_full	Ambient noise exposure induces long-term adaptations in adult brainstem neurons
title_fullStr	Ambient noise exposure induces long-term adaptations in adult brainstem neurons
title_full_unstemmed	Ambient noise exposure induces long-term adaptations in adult brainstem neurons
title_sort	ambient noise exposure induces long-term adaptations in adult brainstem neurons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bda93caa9625422ca5ef9d02ad1e8c61
work_keys_str_mv	AT idasiveke ambientnoiseexposureinduceslongtermadaptationsinadultbrainstemneurons AT mikehmyoga ambientnoiseexposureinduceslongtermadaptationsinadultbrainstemneurons AT benediktgrothe ambientnoiseexposureinduceslongtermadaptationsinadultbrainstemneurons AT felixfelmy ambientnoiseexposureinduceslongtermadaptationsinadultbrainstemneurons
_version_	1718395843503980544

Ambient noise exposure induces long-term adaptations in adult brainstem neurons

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