Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes

Congying Liu,1 Junhong Pan,1 Song Wen,1 Thiquynhnga Nguyen,1 Dongxiang Xu,1 Chaoxun Wang,1 Xinlu Yuan,1 Zhongqiu Wen,2 Ligang Zhou1,3 1Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China; 2Department of Information Center, S...

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Autores principales:	Liu C, Pan J, Wen S, Nguyen T, Xu D, Wang C, Yuan X, Wen Z, Zhou L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	type 2 diabetes thyroid-stimulating hormone bone mineral density menopause Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/bda9c37983a04f6a9f5c933b97706d37
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spelling	oai:doaj.org-article:bda9c37983a04f6a9f5c933b97706d372021-12-02T16:51:44ZLow TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes1178-7007https://doaj.org/article/bda9c37983a04f6a9f5c933b97706d372021-05-01T00:00:00Zhttps://www.dovepress.com/low-tsh-levels-within-euthyroid-range-could-play-a-negative-role-on-bo-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Congying Liu,1 Junhong Pan,1 Song Wen,1 Thiquynhnga Nguyen,1 Dongxiang Xu,1 Chaoxun Wang,1 Xinlu Yuan,1 Zhongqiu Wen,2 Ligang Zhou1,3 1Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China; 2Department of Information Center, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China; 3Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, 2800 Gongwei Road, Huinan Town, Pudong New Area, Shanghai, 201399, People’s Republic of ChinaTel +8613611927616Email zhouligang@yahoo.comObjective: We aimed to evaluate the relationship between thyroid-stimulating hormone (TSH) and bone mineral density (BMD) in euthyroid type 2 diabetes (T2D).Methods: This retrospective analysis enrolled 439 T2D patients with normal thyroid function, including 226 males and 213 females. All the female patients were postmenopausal. Serum glycosylated hemoglobin A1c (HbA1c), TSH, free triiodothyronine (FT3), and free thyroxine (FT4) concentrations were analyzed. BMD of the lumbar spine (L1–L4), femoral neck, and hip joint was determined using dual-energy X-ray absorptiometry.Results: The patients were grouped based on tri-sectional quantiles of the TSH levels: 0.55&sim; 1.70mIU/L (Group 1), 1.71&sim; 2.58mIU/L (Group 2), and 2.59&sim; 4.74mIU/L (Group 3). Our data showed that, in male patients, no difference in BMD was identified among groups. In postmenopausal women, unlike at the lumbar spine (P = 0.459), the mean BMD at the femoral neck (P = 0.014) and hip joint (P = 0.014) had a statistical difference among groups and increased with TSH level. In addition, our analysis demonstrated that TSH levels shown no correlation with BMD at all sites in males. However, in females, BMD at the femoral neck (r = 0.156, P = 0.023) and hip joint (r = 0.172, P = 0.012) had a positive correlation with TSH levels. After adjusting for age and BMI, multiple regression analysis showed that TSH levels influenced BMD at the femoral neck (β = 0.188, P = 0.001) and hip joint (β = 0.204, P = 0.001) in female patients.Conclusion: In summary, our data demonstrates that low TSH levels are associated with decreased BMD at the femoral neck and hip joint in postmenopausal T2D women with euthyroidism.Keywords: type 2 diabetes, thyroid-stimulating hormone, bone mineral density, menopauseLiu CPan JWen SNguyen TXu DWang CYuan XWen ZZhou LDove Medical Pressarticletype 2 diabetesthyroid-stimulating hormonebone mineral densitymenopauseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2349-2355 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes thyroid-stimulating hormone bone mineral density menopause Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes thyroid-stimulating hormone bone mineral density menopause Specialties of internal medicine RC581-951 Liu C Pan J Wen S Nguyen T Xu D Wang C Yuan X Wen Z Zhou L Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes
description	Congying Liu,1 Junhong Pan,1 Song Wen,1 Thiquynhnga Nguyen,1 Dongxiang Xu,1 Chaoxun Wang,1 Xinlu Yuan,1 Zhongqiu Wen,2 Ligang Zhou1,3 1Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China; 2Department of Information Center, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China; 3Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, 2800 Gongwei Road, Huinan Town, Pudong New Area, Shanghai, 201399, People’s Republic of ChinaTel +8613611927616Email zhouligang@yahoo.comObjective: We aimed to evaluate the relationship between thyroid-stimulating hormone (TSH) and bone mineral density (BMD) in euthyroid type 2 diabetes (T2D).Methods: This retrospective analysis enrolled 439 T2D patients with normal thyroid function, including 226 males and 213 females. All the female patients were postmenopausal. Serum glycosylated hemoglobin A1c (HbA1c), TSH, free triiodothyronine (FT3), and free thyroxine (FT4) concentrations were analyzed. BMD of the lumbar spine (L1–L4), femoral neck, and hip joint was determined using dual-energy X-ray absorptiometry.Results: The patients were grouped based on tri-sectional quantiles of the TSH levels: 0.55&sim; 1.70mIU/L (Group 1), 1.71&sim; 2.58mIU/L (Group 2), and 2.59&sim; 4.74mIU/L (Group 3). Our data showed that, in male patients, no difference in BMD was identified among groups. In postmenopausal women, unlike at the lumbar spine (P = 0.459), the mean BMD at the femoral neck (P = 0.014) and hip joint (P = 0.014) had a statistical difference among groups and increased with TSH level. In addition, our analysis demonstrated that TSH levels shown no correlation with BMD at all sites in males. However, in females, BMD at the femoral neck (r = 0.156, P = 0.023) and hip joint (r = 0.172, P = 0.012) had a positive correlation with TSH levels. After adjusting for age and BMI, multiple regression analysis showed that TSH levels influenced BMD at the femoral neck (β = 0.188, P = 0.001) and hip joint (β = 0.204, P = 0.001) in female patients.Conclusion: In summary, our data demonstrates that low TSH levels are associated with decreased BMD at the femoral neck and hip joint in postmenopausal T2D women with euthyroidism.Keywords: type 2 diabetes, thyroid-stimulating hormone, bone mineral density, menopause
format	article
author	Liu C Pan J Wen S Nguyen T Xu D Wang C Yuan X Wen Z Zhou L
author_facet	Liu C Pan J Wen S Nguyen T Xu D Wang C Yuan X Wen Z Zhou L
author_sort	Liu C
title	Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes
title_short	Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes
title_full	Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes
title_fullStr	Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes
title_full_unstemmed	Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes
title_sort	low tsh levels within euthyroid range could play a negative role on bone mineral density in postmenopausal women with type 2 diabetes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bda9c37983a04f6a9f5c933b97706d37
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Low TSH Levels Within Euthyroid Range Could Play a Negative Role on Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes

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