A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.

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Autores principales:	Christopher Thomas, Benjamin Wetherall, Mark D. Levasseur, Rebecca J. Harris, Scott T. Kerridge, Jonathan M. G. Higgins, Owen R. Davies, Suzanne Madgwick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdaa966adbcf4843a925b336289c52d4
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spelling	oai:doaj.org-article:bdaa966adbcf4843a925b336289c52d42021-12-02T17:01:15ZA prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes10.1038/s41467-021-24554-22041-1723https://doaj.org/article/bdaa966adbcf4843a925b336289c52d42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24554-2https://doaj.org/toc/2041-1723Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.Christopher ThomasBenjamin WetherallMark D. LevasseurRebecca J. HarrisScott T. KerridgeJonathan M. G. HigginsOwen R. DaviesSuzanne MadgwickNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher Thomas Benjamin Wetherall Mark D. Levasseur Rebecca J. Harris Scott T. Kerridge Jonathan M. G. Higgins Owen R. Davies Suzanne Madgwick A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
description	Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.
format	article
author	Christopher Thomas Benjamin Wetherall Mark D. Levasseur Rebecca J. Harris Scott T. Kerridge Jonathan M. G. Higgins Owen R. Davies Suzanne Madgwick
author_facet	Christopher Thomas Benjamin Wetherall Mark D. Levasseur Rebecca J. Harris Scott T. Kerridge Jonathan M. G. Higgins Owen R. Davies Suzanne Madgwick
author_sort	Christopher Thomas
title	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_short	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_full	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_fullStr	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_full_unstemmed	A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_sort	prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bdaa966adbcf4843a925b336289c52d4
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A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

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