A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.

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Autores principales: Christopher Thomas, Benjamin Wetherall, Mark D. Levasseur, Rebecca J. Harris, Scott T. Kerridge, Jonathan M. G. Higgins, Owen R. Davies, Suzanne Madgwick
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/bdaa966adbcf4843a925b336289c52d4
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spelling oai:doaj.org-article:bdaa966adbcf4843a925b336289c52d42021-12-02T17:01:15ZA prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes10.1038/s41467-021-24554-22041-1723https://doaj.org/article/bdaa966adbcf4843a925b336289c52d42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24554-2https://doaj.org/toc/2041-1723Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.Christopher ThomasBenjamin WetherallMark D. LevasseurRebecca J. HarrisScott T. KerridgeJonathan M. G. HigginsOwen R. DaviesSuzanne MadgwickNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher Thomas
Benjamin Wetherall
Mark D. Levasseur
Rebecca J. Harris
Scott T. Kerridge
Jonathan M. G. Higgins
Owen R. Davies
Suzanne Madgwick
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
description Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.
format article
author Christopher Thomas
Benjamin Wetherall
Mark D. Levasseur
Rebecca J. Harris
Scott T. Kerridge
Jonathan M. G. Higgins
Owen R. Davies
Suzanne Madgwick
author_facet Christopher Thomas
Benjamin Wetherall
Mark D. Levasseur
Rebecca J. Harris
Scott T. Kerridge
Jonathan M. G. Higgins
Owen R. Davies
Suzanne Madgwick
author_sort Christopher Thomas
title A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_short A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_full A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_fullStr A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_full_unstemmed A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
title_sort prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bdaa966adbcf4843a925b336289c52d4
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