A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.
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Nature Portfolio
2021
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oai:doaj.org-article:bdaa966adbcf4843a925b336289c52d42021-12-02T17:01:15ZA prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes10.1038/s41467-021-24554-22041-1723https://doaj.org/article/bdaa966adbcf4843a925b336289c52d42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24554-2https://doaj.org/toc/2041-1723Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression.Christopher ThomasBenjamin WetherallMark D. LevasseurRebecca J. HarrisScott T. KerridgeJonathan M. G. HigginsOwen R. DaviesSuzanne MadgwickNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Christopher Thomas Benjamin Wetherall Mark D. Levasseur Rebecca J. Harris Scott T. Kerridge Jonathan M. G. Higgins Owen R. Davies Suzanne Madgwick A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
description |
Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression. |
format |
article |
author |
Christopher Thomas Benjamin Wetherall Mark D. Levasseur Rebecca J. Harris Scott T. Kerridge Jonathan M. G. Higgins Owen R. Davies Suzanne Madgwick |
author_facet |
Christopher Thomas Benjamin Wetherall Mark D. Levasseur Rebecca J. Harris Scott T. Kerridge Jonathan M. G. Higgins Owen R. Davies Suzanne Madgwick |
author_sort |
Christopher Thomas |
title |
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
title_short |
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
title_full |
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
title_fullStr |
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
title_full_unstemmed |
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
title_sort |
prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/bdaa966adbcf4843a925b336289c52d4 |
work_keys_str_mv |
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