Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
Abstract Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are associated with diabetes, and LQTS patients have...
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Autores principales: | Anniek F. Lubberding, Jinyi Zhang, Morten Lundh, Thomas Svava Nielsen, Mathilde S. Søndergaard, Maria Villadsen, Emil Z. Skovhøj, Geke A. Boer, Jakob B. Hansen, Morten B. Thomsen, Jonas T. Treebak, Jens J. Holst, Jørgen K. Kanters, Thomas Mandrup-Poulsen, Thomas Jespersen, Brice Emanuelli, Signe S. Torekov |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/bdb0c435470a478696e2cc00273a4925 |
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