Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation

Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation that plays a major role in immunosenescence and in development and progression of many diseases. But currently, there are no recognized standard biomarkers to assess SCI levels alone, and SCI is typically meas...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Line Jee Hartmann Rasmussen, Jens Emil Vang Petersen, Jesper Eugen-Olsen
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://doaj.org/article/bdb1e3e2cd714f7ab8dcce84c7ff1e8b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:bdb1e3e2cd714f7ab8dcce84c7ff1e8b
record_format dspace
spelling oai:doaj.org-article:bdb1e3e2cd714f7ab8dcce84c7ff1e8b2021-12-02T10:36:01ZSoluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation1664-322410.3389/fimmu.2021.780641https://doaj.org/article/bdb1e3e2cd714f7ab8dcce84c7ff1e8b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.780641/fullhttps://doaj.org/toc/1664-3224Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation that plays a major role in immunosenescence and in development and progression of many diseases. But currently, there are no recognized standard biomarkers to assess SCI levels alone, and SCI is typically measured by combining biomarkers of acute inflammation and infection, e.g., CRP, IL-6, and TNFα. In this review, we highlight 10 properties and characteristics that are shared by the blood protein soluble urokinase plasminogen activator receptor (suPAR) and SCI, supporting the argument that suPAR is a biomarker of SCI: (1) Expression and release of suPAR is upregulated by immune activation; (2) uPAR and suPAR exert pro-inflammatory functions; (3) suPAR is associated with the amount of circulating immune cells; (4) Blood suPAR levels correlate with the levels of established inflammatory biomarkers; (5) suPAR is minimally affected by acute changes and short-term influences, in contrast to many currently used markers of systemic inflammation; (6) Like SCI, suPAR is non-specifically associated with multiple diseases; (7) suPAR and SCI both predict morbidity and mortality; (8) suPAR and SCI share the same risk factors; (9) suPAR is associated with risk factors and outcomes of inflammation above and beyond other inflammatory biomarkers; (10) The suPAR level can be reduced by anti-inflammatory interventions and treatment of disease. Assessing SCI has the potential to inform risk for morbidity and mortality. Blood suPAR is a newer biomarker which may, in fact, be a biomarker of SCI since it is stably associated with inflammation and immune activation; shares the same risk factors as many age-related diseases; is both elevated by and predicts age-related diseases. There is strong evidence that suPAR is a prognostic marker of adverse events, morbidity, and mortality. It is associated with immune activity and prognosis across diverse conditions, including kidney disease, cardiovascular disease, cancer, diabetes, and inflammatory disorders. Thus, we think it likely represents a common underlying disease-process shared by many diseases; that is, SCI. We review the supporting literature and propose a research agenda that can help test the hypothesis that suPAR indexes SCI, with the potential of becoming the new gold standard for measuring SCI.Line Jee Hartmann RasmussenLine Jee Hartmann RasmussenJens Emil Vang PetersenJesper Eugen-OlsenFrontiers Media S.A.articleinflammationbiomarkersinflammation mediators - bloodC-reactive proteininterleukin-6inflammagingImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic inflammation
biomarkers
inflammation mediators - blood
C-reactive protein
interleukin-6
inflammaging
Immunologic diseases. Allergy
RC581-607
spellingShingle inflammation
biomarkers
inflammation mediators - blood
C-reactive protein
interleukin-6
inflammaging
Immunologic diseases. Allergy
RC581-607
Line Jee Hartmann Rasmussen
Line Jee Hartmann Rasmussen
Jens Emil Vang Petersen
Jesper Eugen-Olsen
Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
description Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation that plays a major role in immunosenescence and in development and progression of many diseases. But currently, there are no recognized standard biomarkers to assess SCI levels alone, and SCI is typically measured by combining biomarkers of acute inflammation and infection, e.g., CRP, IL-6, and TNFα. In this review, we highlight 10 properties and characteristics that are shared by the blood protein soluble urokinase plasminogen activator receptor (suPAR) and SCI, supporting the argument that suPAR is a biomarker of SCI: (1) Expression and release of suPAR is upregulated by immune activation; (2) uPAR and suPAR exert pro-inflammatory functions; (3) suPAR is associated with the amount of circulating immune cells; (4) Blood suPAR levels correlate with the levels of established inflammatory biomarkers; (5) suPAR is minimally affected by acute changes and short-term influences, in contrast to many currently used markers of systemic inflammation; (6) Like SCI, suPAR is non-specifically associated with multiple diseases; (7) suPAR and SCI both predict morbidity and mortality; (8) suPAR and SCI share the same risk factors; (9) suPAR is associated with risk factors and outcomes of inflammation above and beyond other inflammatory biomarkers; (10) The suPAR level can be reduced by anti-inflammatory interventions and treatment of disease. Assessing SCI has the potential to inform risk for morbidity and mortality. Blood suPAR is a newer biomarker which may, in fact, be a biomarker of SCI since it is stably associated with inflammation and immune activation; shares the same risk factors as many age-related diseases; is both elevated by and predicts age-related diseases. There is strong evidence that suPAR is a prognostic marker of adverse events, morbidity, and mortality. It is associated with immune activity and prognosis across diverse conditions, including kidney disease, cardiovascular disease, cancer, diabetes, and inflammatory disorders. Thus, we think it likely represents a common underlying disease-process shared by many diseases; that is, SCI. We review the supporting literature and propose a research agenda that can help test the hypothesis that suPAR indexes SCI, with the potential of becoming the new gold standard for measuring SCI.
format article
author Line Jee Hartmann Rasmussen
Line Jee Hartmann Rasmussen
Jens Emil Vang Petersen
Jesper Eugen-Olsen
author_facet Line Jee Hartmann Rasmussen
Line Jee Hartmann Rasmussen
Jens Emil Vang Petersen
Jesper Eugen-Olsen
author_sort Line Jee Hartmann Rasmussen
title Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
title_short Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
title_full Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
title_fullStr Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
title_full_unstemmed Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation
title_sort soluble urokinase plasminogen activator receptor (supar) as a biomarker of systemic chronic inflammation
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/bdb1e3e2cd714f7ab8dcce84c7ff1e8b
work_keys_str_mv AT linejeehartmannrasmussen solubleurokinaseplasminogenactivatorreceptorsuparasabiomarkerofsystemicchronicinflammation
AT linejeehartmannrasmussen solubleurokinaseplasminogenactivatorreceptorsuparasabiomarkerofsystemicchronicinflammation
AT jensemilvangpetersen solubleurokinaseplasminogenactivatorreceptorsuparasabiomarkerofsystemicchronicinflammation
AT jespereugenolsen solubleurokinaseplasminogenactivatorreceptorsuparasabiomarkerofsystemicchronicinflammation
_version_ 1718396962858860544