Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism

Landomycins are promising anti-cancer agents with the potential to bypass common resistance pathways, but their mechanism of action remains incompletely understood. Here a mechanism is proposed involving intracellular sequential thiol-Michael and oxidation reactions, which depletes endogenous thiols...

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Autores principales: Alessio Terenzi, Mery La Franca, Sushilla van Schoonhoven, Rostyslav Panchuk, Álvaro Martínez, Petra Heffeter, Redding Gober, Christine Pirker, Petra Vician, Christian R. Kowol, Rostyslav Stoika, Luca Salassa, Jürgen Rohr, Walter Berger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/bdb5050705c84bce940244077ea65781
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spelling oai:doaj.org-article:bdb5050705c84bce940244077ea657812021-11-28T12:05:10ZLandomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism10.1038/s42004-021-00600-42399-3669https://doaj.org/article/bdb5050705c84bce940244077ea657812021-11-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00600-4https://doaj.org/toc/2399-3669Landomycins are promising anti-cancer agents with the potential to bypass common resistance pathways, but their mechanism of action remains incompletely understood. Here a mechanism is proposed involving intracellular sequential thiol-Michael and oxidation reactions, which depletes endogenous thiols and induces reactive oxygen species formation.Alessio TerenziMery La FrancaSushilla van SchoonhovenRostyslav PanchukÁlvaro MartínezPetra HeffeterRedding GoberChristine PirkerPetra VicianChristian R. KowolRostyslav StoikaLuca SalassaJürgen RohrWalter BergerNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chemistry
QD1-999
spellingShingle Chemistry
QD1-999
Alessio Terenzi
Mery La Franca
Sushilla van Schoonhoven
Rostyslav Panchuk
Álvaro Martínez
Petra Heffeter
Redding Gober
Christine Pirker
Petra Vician
Christian R. Kowol
Rostyslav Stoika
Luca Salassa
Jürgen Rohr
Walter Berger
Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
description Landomycins are promising anti-cancer agents with the potential to bypass common resistance pathways, but their mechanism of action remains incompletely understood. Here a mechanism is proposed involving intracellular sequential thiol-Michael and oxidation reactions, which depletes endogenous thiols and induces reactive oxygen species formation.
format article
author Alessio Terenzi
Mery La Franca
Sushilla van Schoonhoven
Rostyslav Panchuk
Álvaro Martínez
Petra Heffeter
Redding Gober
Christine Pirker
Petra Vician
Christian R. Kowol
Rostyslav Stoika
Luca Salassa
Jürgen Rohr
Walter Berger
author_facet Alessio Terenzi
Mery La Franca
Sushilla van Schoonhoven
Rostyslav Panchuk
Álvaro Martínez
Petra Heffeter
Redding Gober
Christine Pirker
Petra Vician
Christian R. Kowol
Rostyslav Stoika
Luca Salassa
Jürgen Rohr
Walter Berger
author_sort Alessio Terenzi
title Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
title_short Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
title_full Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
title_fullStr Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
title_full_unstemmed Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
title_sort landomycins as glutathione-depleting agents and natural fluorescent probes for cellular michael adduct-dependent quinone metabolism
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/bdb5050705c84bce940244077ea65781
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