Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease
IRF5 is a potential target for therapy in systemic lupus erythematosus (SLE). Here the authors show using mouse SLE-like models that genetic or chemical inhibition of IRF5 after SLE onset could be more effective than, or an add on for, currently utilised type I interferon inhibition.
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Nature Portfolio
2021
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oai:doaj.org-article:bdb59bea8b1b42119ff3a063d9c303ba2021-12-02T16:43:31ZGenetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease10.1038/s41467-021-24609-42041-1723https://doaj.org/article/bdb59bea8b1b42119ff3a063d9c303ba2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24609-4https://doaj.org/toc/2041-1723IRF5 is a potential target for therapy in systemic lupus erythematosus (SLE). Here the authors show using mouse SLE-like models that genetic or chemical inhibition of IRF5 after SLE onset could be more effective than, or an add on for, currently utilised type I interferon inhibition.Tatsuma BanMasako KikuchiGo R. SatoAkio ManabeNoriko TagataKayo HaritaAkira NishiyamaKenichi NishimuraRyusuke YoshimiYohei KirinoHideyuki YanaiYoshiko MatsumotoShuichi SuzukiHiroe HiharaMasashi ItoKappei TsukaharaKentaro YoshimatsuTadashi YamamotoTadatsugu TaniguchiHideaki NakajimaShuichi ItoTomohiko TamuraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tatsuma Ban Masako Kikuchi Go R. Sato Akio Manabe Noriko Tagata Kayo Harita Akira Nishiyama Kenichi Nishimura Ryusuke Yoshimi Yohei Kirino Hideyuki Yanai Yoshiko Matsumoto Shuichi Suzuki Hiroe Hihara Masashi Ito Kappei Tsukahara Kentaro Yoshimatsu Tadashi Yamamoto Tadatsugu Taniguchi Hideaki Nakajima Shuichi Ito Tomohiko Tamura Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease |
| description |
IRF5 is a potential target for therapy in systemic lupus erythematosus (SLE). Here the authors show using mouse SLE-like models that genetic or chemical inhibition of IRF5 after SLE onset could be more effective than, or an add on for, currently utilised type I interferon inhibition. |
| format |
article |
| author |
Tatsuma Ban Masako Kikuchi Go R. Sato Akio Manabe Noriko Tagata Kayo Harita Akira Nishiyama Kenichi Nishimura Ryusuke Yoshimi Yohei Kirino Hideyuki Yanai Yoshiko Matsumoto Shuichi Suzuki Hiroe Hihara Masashi Ito Kappei Tsukahara Kentaro Yoshimatsu Tadashi Yamamoto Tadatsugu Taniguchi Hideaki Nakajima Shuichi Ito Tomohiko Tamura |
| author_facet |
Tatsuma Ban Masako Kikuchi Go R. Sato Akio Manabe Noriko Tagata Kayo Harita Akira Nishiyama Kenichi Nishimura Ryusuke Yoshimi Yohei Kirino Hideyuki Yanai Yoshiko Matsumoto Shuichi Suzuki Hiroe Hihara Masashi Ito Kappei Tsukahara Kentaro Yoshimatsu Tadashi Yamamoto Tadatsugu Taniguchi Hideaki Nakajima Shuichi Ito Tomohiko Tamura |
| author_sort |
Tatsuma Ban |
| title |
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease |
| title_short |
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease |
| title_full |
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease |
| title_fullStr |
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease |
| title_full_unstemmed |
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease |
| title_sort |
genetic and chemical inhibition of irf5 suppresses pre-existing mouse lupus-like disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/bdb59bea8b1b42119ff3a063d9c303ba |
| work_keys_str_mv |
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