Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility

Purpose: Ankylosing spondylitis (AS) not only results in pathological ossification of the spine, but can also be associated with osteoporosis. Due to the presence of syndesmophytes and possible involvement of the hip joints, classical dual X-ray absorptiometry (DXA) is of limited use in patients wit...

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Autores principales:	Anna Nowakowska-Płaza, Jakub Wroński, Iwona Sudoł-Szopińska, Piotr Głuszko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoporosis ankylosing spondylitis DXA trabecular bone score Medicine R
Acceso en línea:	https://doaj.org/article/bdb5bb94366b4740bf763bab095266ec
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spelling	oai:doaj.org-article:bdb5bb94366b4740bf763bab095266ec2021-11-25T18:02:12ZTrabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility10.3390/jcm102253732077-0383https://doaj.org/article/bdb5bb94366b4740bf763bab095266ec2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5373https://doaj.org/toc/2077-0383Purpose: Ankylosing spondylitis (AS) not only results in pathological ossification of the spine, but can also be associated with osteoporosis. Due to the presence of syndesmophytes and possible involvement of the hip joints, classical dual X-ray absorptiometry (DXA) is of limited use in patients with advanced stages of AS. Trabecular bone score (TBS) is a method complementary to DXA, providing additional information about bone microarchitecture. There is a growing body of evidence for the usefulness of TBS in AS patients. The aim of this study was to assess the clinical utility of TBS in patients with AS. Methods: Patients with AS underwent DXA with additional TBS assessment. A cross-sectional analysis of the frequency of osteoporosis and bone microarchitecture deterioration and their association with patients’ characteristics was done. Results: A total of 51 male patients, mean age 40.7 years, were enrolled. Osteoporosis was diagnosed in seven patients (13.7%). Lumbar bone mineral density (BMD) was higher (<i>p</i> < 0.001) than femoral BMD, indicating abnormal BMD readings in the spine caused by syndesmophytes. Patients with DXA-diagnosed osteoporosis had lower TBS (<i>p</i> = 0.03) and TBS T-score (<i>p</i> = 0.043) values compared to patients without osteoporosis. However, disturbed bone microarchitecture (TBS < 1.23) was present in only three patients (5.9%). None of the patients had a history of an osteoporotic fracture. A lower TBS T-score (<i>p</i> = 0.032) was demonstrated in patients with sacroiliitis grade 4 than in patients with sacroiliitis grade 2, with no significant differences in BMD and T-score values. Conclusion: Among patients with early AS, the clinical utility of TBS is limited—it does not add value to DXA.Anna Nowakowska-PłazaJakub WrońskiIwona Sudoł-SzopińskaPiotr GłuszkoMDPI AGarticleosteoporosisankylosing spondylitisDXAtrabecular bone scoreMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5373, p 5373 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis ankylosing spondylitis DXA trabecular bone score Medicine R
spellingShingle	osteoporosis ankylosing spondylitis DXA trabecular bone score Medicine R Anna Nowakowska-Płaza Jakub Wroński Iwona Sudoł-Szopińska Piotr Głuszko Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility
description	Purpose: Ankylosing spondylitis (AS) not only results in pathological ossification of the spine, but can also be associated with osteoporosis. Due to the presence of syndesmophytes and possible involvement of the hip joints, classical dual X-ray absorptiometry (DXA) is of limited use in patients with advanced stages of AS. Trabecular bone score (TBS) is a method complementary to DXA, providing additional information about bone microarchitecture. There is a growing body of evidence for the usefulness of TBS in AS patients. The aim of this study was to assess the clinical utility of TBS in patients with AS. Methods: Patients with AS underwent DXA with additional TBS assessment. A cross-sectional analysis of the frequency of osteoporosis and bone microarchitecture deterioration and their association with patients’ characteristics was done. Results: A total of 51 male patients, mean age 40.7 years, were enrolled. Osteoporosis was diagnosed in seven patients (13.7%). Lumbar bone mineral density (BMD) was higher (<i>p</i> < 0.001) than femoral BMD, indicating abnormal BMD readings in the spine caused by syndesmophytes. Patients with DXA-diagnosed osteoporosis had lower TBS (<i>p</i> = 0.03) and TBS T-score (<i>p</i> = 0.043) values compared to patients without osteoporosis. However, disturbed bone microarchitecture (TBS < 1.23) was present in only three patients (5.9%). None of the patients had a history of an osteoporotic fracture. A lower TBS T-score (<i>p</i> = 0.032) was demonstrated in patients with sacroiliitis grade 4 than in patients with sacroiliitis grade 2, with no significant differences in BMD and T-score values. Conclusion: Among patients with early AS, the clinical utility of TBS is limited—it does not add value to DXA.
format	article
author	Anna Nowakowska-Płaza Jakub Wroński Iwona Sudoł-Szopińska Piotr Głuszko
author_facet	Anna Nowakowska-Płaza Jakub Wroński Iwona Sudoł-Szopińska Piotr Głuszko
author_sort	Anna Nowakowska-Płaza
title	Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility
title_short	Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility
title_full	Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility
title_fullStr	Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility
title_full_unstemmed	Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility
title_sort	trabecular bone score (tbs) in patients with early ankylosing spondylitis—limited utility
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bdb5bb94366b4740bf763bab095266ec
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Trabecular Bone Score (TBS) in Patients with Early Ankylosing Spondylitis—Limited Utility

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