Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats

Arsenic (As) poisoning is widespread due to exposure to pollution. The toxic level of (As) causes oxidative stress-induced aging and tissue damage. Since melatonin (MLT) has anti-oxidant and anti-aging properties, we aimed to evaluate the protective effect of MLT against the toxicity of sodium arsen...

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Autores principales:	Maryam Baeeri, Tina Didari, Madiha Khalid, Solmaz Mohammadi-Nejad, Seyed Mojtaba Daghighi, Ramtin Farhadi, Mahban Rahimifard, Zahra Bayrami, Hamed Haghi-Aminjan, Roham Foroumadi, Mahdi Gholami, Mohammad Abdollahi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aging Klotho Melatonin sodium arsenite TERT TRADD Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/bdb65ff92cda4d3b84b3db69446027e4
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spelling	oai:doaj.org-article:bdb65ff92cda4d3b84b3db69446027e42021-11-11T18:34:45ZMolecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats10.3390/molecules262166031420-3049https://doaj.org/article/bdb65ff92cda4d3b84b3db69446027e42021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6603https://doaj.org/toc/1420-3049Arsenic (As) poisoning is widespread due to exposure to pollution. The toxic level of (As) causes oxidative stress-induced aging and tissue damage. Since melatonin (MLT) has anti-oxidant and anti-aging properties, we aimed to evaluate the protective effect of MLT against the toxicity of sodium arsenite (NaAsO<sub>2</sub>). Healthy male NMRI mice were divided into eight different groups. The control group received a standard regular diet. Other groups were treated with varying diets, including MLT alone, NaAsO<sub>2</sub>, and NaAsO<sub>2</sub> plus MLT. After one month of treatment, biochemical and pathological tests were performed on blood, heart, and lung tissue samples. NaAsO<sub>2</sub> increased the levels of TNF-α, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. In contrast, MLT reduced MDA, ROS, HMGB1, lactate, and TNF-α enhanced the mRNA expression of KL, and suppressed the mRNA expression of the TERT and TRADD genes. Thus, MLT confers potent protection against NaAsO<sub>2</sub>- induced tissue injury and oxidative stress.Maryam BaeeriTina DidariMadiha KhalidSolmaz Mohammadi-NejadSeyed Mojtaba DaghighiRamtin FarhadiMahban RahimifardZahra BayramiHamed Haghi-AminjanRoham ForoumadiMahdi GholamiMohammad AbdollahiMDPI AGarticleagingKlothoMelatoninsodium arseniteTERTTRADDOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6603, p 6603 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging Klotho Melatonin sodium arsenite TERT TRADD Organic chemistry QD241-441
spellingShingle	aging Klotho Melatonin sodium arsenite TERT TRADD Organic chemistry QD241-441 Maryam Baeeri Tina Didari Madiha Khalid Solmaz Mohammadi-Nejad Seyed Mojtaba Daghighi Ramtin Farhadi Mahban Rahimifard Zahra Bayrami Hamed Haghi-Aminjan Roham Foroumadi Mahdi Gholami Mohammad Abdollahi Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats
description	Arsenic (As) poisoning is widespread due to exposure to pollution. The toxic level of (As) causes oxidative stress-induced aging and tissue damage. Since melatonin (MLT) has anti-oxidant and anti-aging properties, we aimed to evaluate the protective effect of MLT against the toxicity of sodium arsenite (NaAsO<sub>2</sub>). Healthy male NMRI mice were divided into eight different groups. The control group received a standard regular diet. Other groups were treated with varying diets, including MLT alone, NaAsO<sub>2</sub>, and NaAsO<sub>2</sub> plus MLT. After one month of treatment, biochemical and pathological tests were performed on blood, heart, and lung tissue samples. NaAsO<sub>2</sub> increased the levels of TNF-α, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. In contrast, MLT reduced MDA, ROS, HMGB1, lactate, and TNF-α enhanced the mRNA expression of KL, and suppressed the mRNA expression of the TERT and TRADD genes. Thus, MLT confers potent protection against NaAsO<sub>2</sub>- induced tissue injury and oxidative stress.
format	article
author	Maryam Baeeri Tina Didari Madiha Khalid Solmaz Mohammadi-Nejad Seyed Mojtaba Daghighi Ramtin Farhadi Mahban Rahimifard Zahra Bayrami Hamed Haghi-Aminjan Roham Foroumadi Mahdi Gholami Mohammad Abdollahi
author_facet	Maryam Baeeri Tina Didari Madiha Khalid Solmaz Mohammadi-Nejad Seyed Mojtaba Daghighi Ramtin Farhadi Mahban Rahimifard Zahra Bayrami Hamed Haghi-Aminjan Roham Foroumadi Mahdi Gholami Mohammad Abdollahi
author_sort	Maryam Baeeri
title	Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats
title_short	Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats
title_full	Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats
title_fullStr	Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats
title_full_unstemmed	Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats
title_sort	molecular evidence of the inhibitory potential of melatonin against naaso<sub>2</sub>-induced aging in male rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bdb65ff92cda4d3b84b3db69446027e4
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Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO<sub>2</sub>-Induced Aging in Male Rats

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