Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism

Abstract Endogenous arginine derivatives homoarginine, asymmetric dimethylarginine (ADMA) and symmetric dimethyarginine (SDMA) are independent mortality predictors in atherosclerotic cardiovascular disease (CVD). Our study reports the first analysis, whether homoarginine, ADMA and SDMA predict venou...

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Autores principales:	Roman N. Rodionov, Jan Beyer-Westendorf, Stefanie M. Bode-Böger, Lisa Eggebrecht, Stavros Konstantinides, Jens Martens-Lobenhoffer, Markus Nagler, Jürgen Prochaska, Philipp Wild
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bdb93f042e6d4a41b17f2f9ab568b00b
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spelling	oai:doaj.org-article:bdb93f042e6d4a41b17f2f9ab568b00b2021-12-02T14:49:43ZHomoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism10.1038/s41598-021-88986-y2045-2322https://doaj.org/article/bdb93f042e6d4a41b17f2f9ab568b00b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88986-yhttps://doaj.org/toc/2045-2322Abstract Endogenous arginine derivatives homoarginine, asymmetric dimethylarginine (ADMA) and symmetric dimethyarginine (SDMA) are independent mortality predictors in atherosclerotic cardiovascular disease (CVD). Our study reports the first analysis, whether homoarginine, ADMA and SDMA predict venous thromboembolism (VTE) recurrence and overall mortality in patients with suspected acute VTE. We assessed serum levels of homoarginine, ADMA and SDMA by LC–MS/MS in 865 individuals from a prospective consecutive cohort of patients with clinical suspicion of VTE. The median follow-up time for mortality was 1196 days. VTE was confirmed by imaging in 418 patients and excluded in 447 patients. Low levels of homoarginine and high levels of ADMA or SDMA independently predicted all-cause mortality after adjustment for sex, age, oral anticoagulants, body mass index, arterial hypertension, diabetes mellitus, smoking, dyslipidemia, chronic heart failure, history of stroke, creatinine and cancer both in patients with VTE and without VTE. Interestingly, none of those parameters was predictive for VTE recurrence. We provide the first report that low circulating levels of homoarginine and high circulating levels of ADMA and SDMA independently predict all-cause mortality in patients with suspected VTE. These parameters might serve as markers of “frailty” and should be considered for future risk stratification approaches in this clinical population. Taking into account that homoarginine supplementation is protective in animal models of CVD and safe in healthy human volunteers, our study provides the basis for future homoarginine supplementation studies in patients with suspected VTE to investigate possible direct protective effects of homoarginine in this population.Roman N. RodionovJan Beyer-WestendorfStefanie M. Bode-BögerLisa EggebrechtStavros KonstantinidesJens Martens-LobenhofferMarkus NaglerJürgen ProchaskaPhilipp WildNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roman N. Rodionov Jan Beyer-Westendorf Stefanie M. Bode-Böger Lisa Eggebrecht Stavros Konstantinides Jens Martens-Lobenhoffer Markus Nagler Jürgen Prochaska Philipp Wild Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
description	Abstract Endogenous arginine derivatives homoarginine, asymmetric dimethylarginine (ADMA) and symmetric dimethyarginine (SDMA) are independent mortality predictors in atherosclerotic cardiovascular disease (CVD). Our study reports the first analysis, whether homoarginine, ADMA and SDMA predict venous thromboembolism (VTE) recurrence and overall mortality in patients with suspected acute VTE. We assessed serum levels of homoarginine, ADMA and SDMA by LC–MS/MS in 865 individuals from a prospective consecutive cohort of patients with clinical suspicion of VTE. The median follow-up time for mortality was 1196 days. VTE was confirmed by imaging in 418 patients and excluded in 447 patients. Low levels of homoarginine and high levels of ADMA or SDMA independently predicted all-cause mortality after adjustment for sex, age, oral anticoagulants, body mass index, arterial hypertension, diabetes mellitus, smoking, dyslipidemia, chronic heart failure, history of stroke, creatinine and cancer both in patients with VTE and without VTE. Interestingly, none of those parameters was predictive for VTE recurrence. We provide the first report that low circulating levels of homoarginine and high circulating levels of ADMA and SDMA independently predict all-cause mortality in patients with suspected VTE. These parameters might serve as markers of “frailty” and should be considered for future risk stratification approaches in this clinical population. Taking into account that homoarginine supplementation is protective in animal models of CVD and safe in healthy human volunteers, our study provides the basis for future homoarginine supplementation studies in patients with suspected VTE to investigate possible direct protective effects of homoarginine in this population.
format	article
author	Roman N. Rodionov Jan Beyer-Westendorf Stefanie M. Bode-Böger Lisa Eggebrecht Stavros Konstantinides Jens Martens-Lobenhoffer Markus Nagler Jürgen Prochaska Philipp Wild
author_facet	Roman N. Rodionov Jan Beyer-Westendorf Stefanie M. Bode-Böger Lisa Eggebrecht Stavros Konstantinides Jens Martens-Lobenhoffer Markus Nagler Jürgen Prochaska Philipp Wild
author_sort	Roman N. Rodionov
title	Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
title_short	Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
title_full	Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
title_fullStr	Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
title_full_unstemmed	Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
title_sort	homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bdb93f042e6d4a41b17f2f9ab568b00b
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Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism

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