Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three...
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Nature Portfolio
2020
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oai:doaj.org-article:bdbb435b4d944496b157432e614c287b2021-12-02T15:39:25ZImidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology10.1038/s41467-020-19589-w2041-1723https://doaj.org/article/bdbb435b4d944496b157432e614c287b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19589-whttps://doaj.org/toc/2041-1723Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.Antonio MolinaroPierre Bel LassenMarcus HenricssonHao WuSolia AdriouchEugeni BeldaRima ChakarounTrine NielsenPer-Olof BerghChristine RouaultSébastien AndréFlorian MarquetFabrizio AndreelliJoe-Elie SalemKaren AssmannJean-Philippe BastardSofia ForslundEmmanuelle Le ChatelierGwen FalonyNicolas PonsEdi PriftiBenoit QuinquisHugo RoumeSara Vieira-SilvaTue H. HansenHelle Krogh PedersenChristian LewinterNadja B. SønderskovThe MetaCardis ConsortiumLars KøberHenrik VestergaardTorben HansenJean-Daniel ZuckerPilar GalanMarc-Emmanuel DumasJeroen RaesJean-Michel OppertIvica LetunicJens NielsenPeer BorkS. Dusko EhrlichMichael StumvollOluf PedersenJudith Aron-WisnewskyKarine ClémentFredrik BäckhedNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Antonio Molinaro Pierre Bel Lassen Marcus Henricsson Hao Wu Solia Adriouch Eugeni Belda Rima Chakaroun Trine Nielsen Per-Olof Bergh Christine Rouault Sébastien André Florian Marquet Fabrizio Andreelli Joe-Elie Salem Karen Assmann Jean-Philippe Bastard Sofia Forslund Emmanuelle Le Chatelier Gwen Falony Nicolas Pons Edi Prifti Benoit Quinquis Hugo Roume Sara Vieira-Silva Tue H. Hansen Helle Krogh Pedersen Christian Lewinter Nadja B. Sønderskov The MetaCardis Consortium Lars Køber Henrik Vestergaard Torben Hansen Jean-Daniel Zucker Pilar Galan Marc-Emmanuel Dumas Jeroen Raes Jean-Michel Oppert Ivica Letunic Jens Nielsen Peer Bork S. Dusko Ehrlich Michael Stumvoll Oluf Pedersen Judith Aron-Wisnewsky Karine Clément Fredrik Bäckhed Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| description |
Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine. |
| format |
article |
| author |
Antonio Molinaro Pierre Bel Lassen Marcus Henricsson Hao Wu Solia Adriouch Eugeni Belda Rima Chakaroun Trine Nielsen Per-Olof Bergh Christine Rouault Sébastien André Florian Marquet Fabrizio Andreelli Joe-Elie Salem Karen Assmann Jean-Philippe Bastard Sofia Forslund Emmanuelle Le Chatelier Gwen Falony Nicolas Pons Edi Prifti Benoit Quinquis Hugo Roume Sara Vieira-Silva Tue H. Hansen Helle Krogh Pedersen Christian Lewinter Nadja B. Sønderskov The MetaCardis Consortium Lars Køber Henrik Vestergaard Torben Hansen Jean-Daniel Zucker Pilar Galan Marc-Emmanuel Dumas Jeroen Raes Jean-Michel Oppert Ivica Letunic Jens Nielsen Peer Bork S. Dusko Ehrlich Michael Stumvoll Oluf Pedersen Judith Aron-Wisnewsky Karine Clément Fredrik Bäckhed |
| author_facet |
Antonio Molinaro Pierre Bel Lassen Marcus Henricsson Hao Wu Solia Adriouch Eugeni Belda Rima Chakaroun Trine Nielsen Per-Olof Bergh Christine Rouault Sébastien André Florian Marquet Fabrizio Andreelli Joe-Elie Salem Karen Assmann Jean-Philippe Bastard Sofia Forslund Emmanuelle Le Chatelier Gwen Falony Nicolas Pons Edi Prifti Benoit Quinquis Hugo Roume Sara Vieira-Silva Tue H. Hansen Helle Krogh Pedersen Christian Lewinter Nadja B. Sønderskov The MetaCardis Consortium Lars Køber Henrik Vestergaard Torben Hansen Jean-Daniel Zucker Pilar Galan Marc-Emmanuel Dumas Jeroen Raes Jean-Michel Oppert Ivica Letunic Jens Nielsen Peer Bork S. Dusko Ehrlich Michael Stumvoll Oluf Pedersen Judith Aron-Wisnewsky Karine Clément Fredrik Bäckhed |
| author_sort |
Antonio Molinaro |
| title |
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| title_short |
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| title_full |
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| title_fullStr |
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| title_full_unstemmed |
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| title_sort |
imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/bdbb435b4d944496b157432e614c287b |
| work_keys_str_mv |
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