A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.

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Bibliographic Details
Main Authors:	Ying Fu, Zhen Zhang, Jared Sheehan, Yuval Avnir, Callie Ridenour, Thomas Sachnik, Jiusong Sun, M. Jaber Hossain, Li-Mei Chen, Quan Zhu, Ruben O. Donis, Wayne A. Marasco
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/bdbf5311bd834c67bd4c3bb2bd03af22
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spelling	oai:doaj.org-article:bdbf5311bd834c67bd4c3bb2bd03af222021-12-02T16:58:11ZA broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve10.1038/ncomms127802041-1723https://doaj.org/article/bdbf5311bd834c67bd4c3bb2bd03af222016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12780https://doaj.org/toc/2041-1723A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.Ying FuZhen ZhangJared SheehanYuval AvnirCallie RidenourThomas SachnikJiusong SunM. Jaber HossainLi-Mei ChenQuan ZhuRuben O. DonisWayne A. MarascoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Fu Zhen Zhang Jared Sheehan Yuval Avnir Callie Ridenour Thomas Sachnik Jiusong Sun M. Jaber Hossain Li-Mei Chen Quan Zhu Ruben O. Donis Wayne A. Marasco A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
description	A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.
format	article
author	Ying Fu Zhen Zhang Jared Sheehan Yuval Avnir Callie Ridenour Thomas Sachnik Jiusong Sun M. Jaber Hossain Li-Mei Chen Quan Zhu Ruben O. Donis Wayne A. Marasco
author_facet	Ying Fu Zhen Zhang Jared Sheehan Yuval Avnir Callie Ridenour Thomas Sachnik Jiusong Sun M. Jaber Hossain Li-Mei Chen Quan Zhu Ruben O. Donis Wayne A. Marasco
author_sort	Ying Fu
title	A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_short	A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_full	A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_fullStr	A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_full_unstemmed	A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
title_sort	broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory b cells to evolve
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bdbf5311bd834c67bd4c3bb2bd03af22
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A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve

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