A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
A major goal of vaccine design is to protect against a broad range of pathogen strains. Here the authors isolate a new broadly neutralizing antibody against influenza haemagglutinin from human memory B cells, and identify mutations that increase and broaden the neutralization towards H5 HA subtype.
Guardado en:
Autores principales: | Ying Fu, Zhen Zhang, Jared Sheehan, Yuval Avnir, Callie Ridenour, Thomas Sachnik, Jiusong Sun, M. Jaber Hossain, Li-Mei Chen, Quan Zhu, Ruben O. Donis, Wayne A. Marasco |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
|
Materias: | |
Acceso en línea: | https://doaj.org/article/bdbf5311bd834c67bd4c3bb2bd03af22 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses
por: Alireza Heidari, et al.
Publicado: (2018) -
Unique features of a recombinant haemagglutinin influenza vaccine that influence vaccine performance
por: Arun B. Arunachalam, et al.
Publicado: (2021) -
The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design
por: Larissa Dirr, et al.
Publicado: (2017) -
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies.
por: Devin Sok, et al.
Publicado: (2013) -
Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data.
por: Andrew L Ferguson, et al.
Publicado: (2013)