A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus

Abstract It has been suggested that the dentate gyrus, particularly its new neurons generated via adult neurogenesis, is involved in memory acquisition and recall. Here, we trained rats in two types of Morris water maze tasks that are differentially associated with these two memory processes, and ex...

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Autores principales:	Ida E. J. Aasebø, Ameya Sanjay Kasture, Marzia Passeggeri, Ayumu Tashiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bdc3769e48724ed2abdff128d5ae5a26
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spelling	oai:doaj.org-article:bdc3769e48724ed2abdff128d5ae5a262021-12-02T12:32:21ZA behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus10.1038/s41598-018-25331-w2045-2322https://doaj.org/article/bdc3769e48724ed2abdff128d5ae5a262018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25331-whttps://doaj.org/toc/2045-2322Abstract It has been suggested that the dentate gyrus, particularly its new neurons generated via adult neurogenesis, is involved in memory acquisition and recall. Here, we trained rats in two types of Morris water maze tasks that are differentially associated with these two memory processes, and examined whether new neurons are differently affected by the two tasks performed during the second week of neuronal birth. Our results indicate that the task involving more opportunities to acquire new information better supports the survival of new neurons. Further, we assessed whether the two tasks differentially induce the expression of an immediate early gene, Zif268, which is known to be induced by neuronal activation. While the two tasks differentially induce Zif268 expression in the dentate gyrus, the proportions of new neurons activated were similar between the two tasks. Thus, we conclude that while the two tasks differentially activate the dentate gyrus, the task involving more opportunities for memory acquisition during the second week of the birth of new neurons better promotes the survival of the new neurons.Ida E. J. AasebøAmeya Sanjay KastureMarzia PasseggeriAyumu TashiroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ida E. J. Aasebø Ameya Sanjay Kasture Marzia Passeggeri Ayumu Tashiro A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
description	Abstract It has been suggested that the dentate gyrus, particularly its new neurons generated via adult neurogenesis, is involved in memory acquisition and recall. Here, we trained rats in two types of Morris water maze tasks that are differentially associated with these two memory processes, and examined whether new neurons are differently affected by the two tasks performed during the second week of neuronal birth. Our results indicate that the task involving more opportunities to acquire new information better supports the survival of new neurons. Further, we assessed whether the two tasks differentially induce the expression of an immediate early gene, Zif268, which is known to be induced by neuronal activation. While the two tasks differentially induce Zif268 expression in the dentate gyrus, the proportions of new neurons activated were similar between the two tasks. Thus, we conclude that while the two tasks differentially activate the dentate gyrus, the task involving more opportunities for memory acquisition during the second week of the birth of new neurons better promotes the survival of the new neurons.
format	article
author	Ida E. J. Aasebø Ameya Sanjay Kasture Marzia Passeggeri Ayumu Tashiro
author_facet	Ida E. J. Aasebø Ameya Sanjay Kasture Marzia Passeggeri Ayumu Tashiro
author_sort	Ida E. J. Aasebø
title	A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
title_short	A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
title_full	A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
title_fullStr	A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
title_full_unstemmed	A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
title_sort	behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bdc3769e48724ed2abdff128d5ae5a26
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A behavioral task with more opportunities for memory acquisition promotes the survival of new neurons in the adult dentate gyrus

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