Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

Abstract In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. In...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yifan Xie, Feng Xie, Lei Zhang, Xiaoxue Zhou, Jun Huang, Fangwei Wang, Jin Jin, Long Zhang, Linghui Zeng, Fangfang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	anti‐tumor immunity anti‐tumor therapy B cells CD4+ T cells CD8+ T cells T‐cell exhaustion Science Q
Acceso en línea:	https://doaj.org/article/bdc420197aec491483222a34465e95ae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bdc420197aec491483222a34465e95ae
record_format	dspace
spelling	oai:doaj.org-article:bdc420197aec491483222a34465e95ae2021-11-17T08:40:31ZTargeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells2198-384410.1002/advs.202101672https://doaj.org/article/bdc420197aec491483222a34465e95ae2021-11-01T00:00:00Zhttps://doi.org/10.1002/advs.202101672https://doaj.org/toc/2198-3844Abstract In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8+ T cells, CD4+ T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.Yifan XieFeng XieLei ZhangXiaoxue ZhouJun HuangFangwei WangJin JinLong ZhangLinghui ZengFangfang ZhouWileyarticleanti‐tumor immunityanti‐tumor therapyB cellsCD4+ T cellsCD8+ T cellsT‐cell exhaustionScienceQENAdvanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti‐tumor immunity anti‐tumor therapy B cells CD4+ T cells CD8+ T cells T‐cell exhaustion Science Q
spellingShingle	anti‐tumor immunity anti‐tumor therapy B cells CD4+ T cells CD8+ T cells T‐cell exhaustion Science Q Yifan Xie Feng Xie Lei Zhang Xiaoxue Zhou Jun Huang Fangwei Wang Jin Jin Long Zhang Linghui Zeng Fangfang Zhou Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
description	Abstract In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8+ T cells, CD4+ T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.
format	article
author	Yifan Xie Feng Xie Lei Zhang Xiaoxue Zhou Jun Huang Fangwei Wang Jin Jin Long Zhang Linghui Zeng Fangfang Zhou
author_facet	Yifan Xie Feng Xie Lei Zhang Xiaoxue Zhou Jun Huang Fangwei Wang Jin Jin Long Zhang Linghui Zeng Fangfang Zhou
author_sort	Yifan Xie
title	Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_short	Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_full	Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_fullStr	Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_full_unstemmed	Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells
title_sort	targeted anti‐tumor immunotherapy using tumor infiltrating cells
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/bdc420197aec491483222a34465e95ae
work_keys_str_mv	AT yifanxie targetedantitumorimmunotherapyusingtumorinfiltratingcells AT fengxie targetedantitumorimmunotherapyusingtumorinfiltratingcells AT leizhang targetedantitumorimmunotherapyusingtumorinfiltratingcells AT xiaoxuezhou targetedantitumorimmunotherapyusingtumorinfiltratingcells AT junhuang targetedantitumorimmunotherapyusingtumorinfiltratingcells AT fangweiwang targetedantitumorimmunotherapyusingtumorinfiltratingcells AT jinjin targetedantitumorimmunotherapyusingtumorinfiltratingcells AT longzhang targetedantitumorimmunotherapyusingtumorinfiltratingcells AT linghuizeng targetedantitumorimmunotherapyusingtumorinfiltratingcells AT fangfangzhou targetedantitumorimmunotherapyusingtumorinfiltratingcells
_version_	1718425694854184960

Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

Ejemplares similares