Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision

Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high sp...

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Autores principales:	Philipp Makowka, Tobias Bruegmann, Vanessa Dusend, Daniela Malan, Thomas Beiert, Michael Hesse, Bernd K. Fleischmann, Philipp Sasse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdc7336dcc0d428d9963e651e1b882f9
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spelling	oai:doaj.org-article:bdc7336dcc0d428d9963e651e1b882f92021-12-02T14:39:17ZOptogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision10.1038/s41467-019-09322-72041-1723https://doaj.org/article/bdc7336dcc0d428d9963e651e1b882f92019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09322-7https://doaj.org/toc/2041-1723Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high spatiotemporal precision.Philipp MakowkaTobias BruegmannVanessa DusendDaniela MalanThomas BeiertMichael HesseBernd K. FleischmannPhilipp SasseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philipp Makowka Tobias Bruegmann Vanessa Dusend Daniela Malan Thomas Beiert Michael Hesse Bernd K. Fleischmann Philipp Sasse Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision
description	Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high spatiotemporal precision.
format	article
author	Philipp Makowka Tobias Bruegmann Vanessa Dusend Daniela Malan Thomas Beiert Michael Hesse Bernd K. Fleischmann Philipp Sasse
author_facet	Philipp Makowka Tobias Bruegmann Vanessa Dusend Daniela Malan Thomas Beiert Michael Hesse Bernd K. Fleischmann Philipp Sasse
author_sort	Philipp Makowka
title	Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision
title_short	Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision
title_full	Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision
title_fullStr	Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision
title_full_unstemmed	Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision
title_sort	optogenetic stimulation of gs-signaling in the heart with high spatio-temporal precision
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bdc7336dcc0d428d9963e651e1b882f9
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Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision

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