Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

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Autores principales:	Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83
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spelling	oai:doaj.org-article:bdc7ccfd4f494ac28c7dce1cb6b33f832021-12-02T15:35:03ZMitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation10.1038/s41467-019-12103-x2041-1723https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f832019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12103-xhttps://doaj.org/toc/2041-1723Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.Alyssa A. LombardiAndrew A. GibbEhtesham ArifDevin W. KolmetzkyDhanendra TomarTimothy S. LuongoPooja JadiyaEmma K. MurrayPawel K. LorkiewiczGyörgy HajnóczkyElizabeth MurphyZoltan P. AranyDaniel P. KellyKenneth B. MarguliesBradford G. HillJohn W. ElrodNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alyssa A. Lombardi Andrew A. Gibb Ehtesham Arif Devin W. Kolmetzky Dhanendra Tomar Timothy S. Luongo Pooja Jadiya Emma K. Murray Pawel K. Lorkiewicz György Hajnóczky Elizabeth Murphy Zoltan P. Arany Daniel P. Kelly Kenneth B. Margulies Bradford G. Hill John W. Elrod Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
description	Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.
format	article
author	Alyssa A. Lombardi Andrew A. Gibb Ehtesham Arif Devin W. Kolmetzky Dhanendra Tomar Timothy S. Luongo Pooja Jadiya Emma K. Murray Pawel K. Lorkiewicz György Hajnóczky Elizabeth Murphy Zoltan P. Arany Daniel P. Kelly Kenneth B. Margulies Bradford G. Hill John W. Elrod
author_facet	Alyssa A. Lombardi Andrew A. Gibb Ehtesham Arif Devin W. Kolmetzky Dhanendra Tomar Timothy S. Luongo Pooja Jadiya Emma K. Murray Pawel K. Lorkiewicz György Hajnóczky Elizabeth Murphy Zoltan P. Arany Daniel P. Kelly Kenneth B. Margulies Bradford G. Hill John W. Elrod
author_sort	Alyssa A. Lombardi
title	Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
title_short	Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
title_full	Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
title_fullStr	Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
title_full_unstemmed	Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
title_sort	mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83
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Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

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