Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

Saved in:
Bibliographic Details
Main Authors: Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83

Similar Items