Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands

A series of six sulfur-bridged dinuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3-thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using vario...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nur Adila Fatin Mohd Khir, Mohd Ridzuan Mohd Abdul Razak, Fariza Juliana Nordin, Nur Rahimah Fitrah Mohd Sofyan, Nur Fadilah Rajab, Rozie Sarip
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	thiosemicarbazone silver complexes antiplasmodial antiproliferative phosphine Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bdc8cc37847d41cda287e1b5d60170e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bdc8cc37847d41cda287e1b5d60170e2
record_format	dspace
spelling	oai:doaj.org-article:bdc8cc37847d41cda287e1b5d60170e22021-12-02T15:56:44ZSynthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands1411-94202460-157810.22146/ijc.57343https://doaj.org/article/bdc8cc37847d41cda287e1b5d60170e22021-05-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/57343https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578A series of six sulfur-bridged dinuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3-thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using various techniques such as elemental analysis, Fourier-transform infrared (FTIR) spectroscopy, as well as 1H, 13C, 31P{1H}s, COSY, and 1H-13C nuclear magnetic resonance (NMR) spectroscopy, it was found that the thiosemicarbazone ligand exists in the form of a thione rather than thiol tautomer. Subsequently, MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell lines, were used to investigate the in vitro antiproliferative activities of these complexes. In all cases, the IC50 values were in the potent micromolar range. Besides, the aforementioned complexes also had good antiplasmodial activity against chloroquine-resistant P. falciparum, as per the results of histidine-rich protein 2 (HRP2) assays and cytotoxicity evaluations of MDBK cells.Nur Adila Fatin Mohd KhirMohd Ridzuan Mohd Abdul RazakFariza Juliana NordinNur Rahimah Fitrah Mohd SofyanNur Fadilah RajabRozie SaripDepartment of Chemistry, Universitas Gadjah Madaarticlethiosemicarbazonesilver complexesantiplasmodialantiproliferativephosphineChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 3, Pp 575-587 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thiosemicarbazone silver complexes antiplasmodial antiproliferative phosphine Chemistry QD1-999
spellingShingle	thiosemicarbazone silver complexes antiplasmodial antiproliferative phosphine Chemistry QD1-999 Nur Adila Fatin Mohd Khir Mohd Ridzuan Mohd Abdul Razak Fariza Juliana Nordin Nur Rahimah Fitrah Mohd Sofyan Nur Fadilah Rajab Rozie Sarip Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands
description	A series of six sulfur-bridged dinuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3-thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using various techniques such as elemental analysis, Fourier-transform infrared (FTIR) spectroscopy, as well as 1H, 13C, 31P{1H}s, COSY, and 1H-13C nuclear magnetic resonance (NMR) spectroscopy, it was found that the thiosemicarbazone ligand exists in the form of a thione rather than thiol tautomer. Subsequently, MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell lines, were used to investigate the in vitro antiproliferative activities of these complexes. In all cases, the IC50 values were in the potent micromolar range. Besides, the aforementioned complexes also had good antiplasmodial activity against chloroquine-resistant P. falciparum, as per the results of histidine-rich protein 2 (HRP2) assays and cytotoxicity evaluations of MDBK cells.
format	article
author	Nur Adila Fatin Mohd Khir Mohd Ridzuan Mohd Abdul Razak Fariza Juliana Nordin Nur Rahimah Fitrah Mohd Sofyan Nur Fadilah Rajab Rozie Sarip
author_facet	Nur Adila Fatin Mohd Khir Mohd Ridzuan Mohd Abdul Razak Fariza Juliana Nordin Nur Rahimah Fitrah Mohd Sofyan Nur Fadilah Rajab Rozie Sarip
author_sort	Nur Adila Fatin Mohd Khir
title	Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands
title_short	Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands
title_full	Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands
title_fullStr	Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands
title_full_unstemmed	Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands
title_sort	synthesis, antiproliferative and antimalarial activities of dinuclear silver(i) complexes with triphenylphosphine and thiosemicarbazones ligands
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/bdc8cc37847d41cda287e1b5d60170e2
work_keys_str_mv	AT nuradilafatinmohdkhir synthesisantiproliferativeandantimalarialactivitiesofdinuclearsilvericomplexeswithtriphenylphosphineandthiosemicarbazonesligands AT mohdridzuanmohdabdulrazak synthesisantiproliferativeandantimalarialactivitiesofdinuclearsilvericomplexeswithtriphenylphosphineandthiosemicarbazonesligands AT farizajuliananordin synthesisantiproliferativeandantimalarialactivitiesofdinuclearsilvericomplexeswithtriphenylphosphineandthiosemicarbazonesligands AT nurrahimahfitrahmohdsofyan synthesisantiproliferativeandantimalarialactivitiesofdinuclearsilvericomplexeswithtriphenylphosphineandthiosemicarbazonesligands AT nurfadilahrajab synthesisantiproliferativeandantimalarialactivitiesofdinuclearsilvericomplexeswithtriphenylphosphineandthiosemicarbazonesligands AT roziesarip synthesisantiproliferativeandantimalarialactivitiesofdinuclearsilvericomplexeswithtriphenylphosphineandthiosemicarbazonesligands
_version_	1718385416748400640

Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands

Ejemplares similares