Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis
Matrix stiffening is a feature of pulmonary fibrosis, and is amplified by lung myofibroblasts. Here the authors find that a6 integrin expression is upregulated on lung myofibroblasts in response to matrix stiffness, and this integrin is required for myofibroblast invasion, and fibrosis in an experim...
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/bdcc48b3a1814acd99c91ba73f818aa8 |
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oai:doaj.org-article:bdcc48b3a1814acd99c91ba73f818aa82021-12-02T14:39:49ZMechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis10.1038/ncomms125642041-1723https://doaj.org/article/bdcc48b3a1814acd99c91ba73f818aa82016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12564https://doaj.org/toc/2041-1723Matrix stiffening is a feature of pulmonary fibrosis, and is amplified by lung myofibroblasts. Here the authors find that a6 integrin expression is upregulated on lung myofibroblasts in response to matrix stiffness, and this integrin is required for myofibroblast invasion, and fibrosis in an experimental disease model.Huaping ChenJing QuXiangwei HuangAshish KurundkarLanyan ZhuNaiheng YangAida VenadoQiang DingGang LiuVeena B. AntonyVictor J. ThannickalYong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Huaping Chen Jing Qu Xiangwei Huang Ashish Kurundkar Lanyan Zhu Naiheng Yang Aida Venado Qiang Ding Gang Liu Veena B. Antony Victor J. Thannickal Yong Zhou Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| description |
Matrix stiffening is a feature of pulmonary fibrosis, and is amplified by lung myofibroblasts. Here the authors find that a6 integrin expression is upregulated on lung myofibroblasts in response to matrix stiffness, and this integrin is required for myofibroblast invasion, and fibrosis in an experimental disease model. |
| format |
article |
| author |
Huaping Chen Jing Qu Xiangwei Huang Ashish Kurundkar Lanyan Zhu Naiheng Yang Aida Venado Qiang Ding Gang Liu Veena B. Antony Victor J. Thannickal Yong Zhou |
| author_facet |
Huaping Chen Jing Qu Xiangwei Huang Ashish Kurundkar Lanyan Zhu Naiheng Yang Aida Venado Qiang Ding Gang Liu Veena B. Antony Victor J. Thannickal Yong Zhou |
| author_sort |
Huaping Chen |
| title |
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| title_short |
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| title_full |
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| title_fullStr |
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| title_full_unstemmed |
Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| title_sort |
mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/bdcc48b3a1814acd99c91ba73f818aa8 |
| work_keys_str_mv |
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| _version_ |
1718390498824028160 |