High mitogenic stimulation arrests angiogenesis

High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high mitogenic stimuli instead arrest angiogenesis...

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Autores principales:	Samuel Pontes-Quero, Macarena Fernández-Chacón, Wen Luo, Federica Francesca Lunella, Verónica Casquero-Garcia, Irene Garcia-Gonzalez, Ana Hermoso, Susana F. Rocha, Mayank Bansal, Rui Benedito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdd178fe974e4a4f962429db249693cf
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spelling	oai:doaj.org-article:bdd178fe974e4a4f962429db249693cf2021-12-02T14:39:03ZHigh mitogenic stimulation arrests angiogenesis10.1038/s41467-019-09875-72041-1723https://doaj.org/article/bdd178fe974e4a4f962429db249693cf2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09875-7https://doaj.org/toc/2041-1723High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high mitogenic stimuli instead arrest angiogenesis due to a bell-shaped dose-response to VEGF and MAPK activity that is counteracted by Notch and p21.Samuel Pontes-QueroMacarena Fernández-ChacónWen LuoFederica Francesca LunellaVerónica Casquero-GarciaIrene Garcia-GonzalezAna HermosoSusana F. RochaMayank BansalRui BeneditoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel Pontes-Quero Macarena Fernández-Chacón Wen Luo Federica Francesca Lunella Verónica Casquero-Garcia Irene Garcia-Gonzalez Ana Hermoso Susana F. Rocha Mayank Bansal Rui Benedito High mitogenic stimulation arrests angiogenesis
description	High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high mitogenic stimuli instead arrest angiogenesis due to a bell-shaped dose-response to VEGF and MAPK activity that is counteracted by Notch and p21.
format	article
author	Samuel Pontes-Quero Macarena Fernández-Chacón Wen Luo Federica Francesca Lunella Verónica Casquero-Garcia Irene Garcia-Gonzalez Ana Hermoso Susana F. Rocha Mayank Bansal Rui Benedito
author_facet	Samuel Pontes-Quero Macarena Fernández-Chacón Wen Luo Federica Francesca Lunella Verónica Casquero-Garcia Irene Garcia-Gonzalez Ana Hermoso Susana F. Rocha Mayank Bansal Rui Benedito
author_sort	Samuel Pontes-Quero
title	High mitogenic stimulation arrests angiogenesis
title_short	High mitogenic stimulation arrests angiogenesis
title_full	High mitogenic stimulation arrests angiogenesis
title_fullStr	High mitogenic stimulation arrests angiogenesis
title_full_unstemmed	High mitogenic stimulation arrests angiogenesis
title_sort	high mitogenic stimulation arrests angiogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bdd178fe974e4a4f962429db249693cf
work_keys_str_mv	AT samuelpontesquero highmitogenicstimulationarrestsangiogenesis AT macarenafernandezchacon highmitogenicstimulationarrestsangiogenesis AT wenluo highmitogenicstimulationarrestsangiogenesis AT federicafrancescalunella highmitogenicstimulationarrestsangiogenesis AT veronicacasquerogarcia highmitogenicstimulationarrestsangiogenesis AT irenegarciagonzalez highmitogenicstimulationarrestsangiogenesis AT anahermoso highmitogenicstimulationarrestsangiogenesis AT susanafrocha highmitogenicstimulationarrestsangiogenesis AT mayankbansal highmitogenicstimulationarrestsangiogenesis AT ruibenedito highmitogenicstimulationarrestsangiogenesis
_version_	1718390793989783552

High mitogenic stimulation arrests angiogenesis

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