Click Chemistry in Natural Product Modification

Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks...

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Autores principales:	Xiang Zhang, Shuning Zhang, Songfeng Zhao, Xuan Wang, Bo Liu, Hongtao Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bdd32c1de0a84da0ac7d7a280a820b0c
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spelling	oai:doaj.org-article:bdd32c1de0a84da0ac7d7a280a820b0c2021-11-17T07:03:05ZClick Chemistry in Natural Product Modification2296-264610.3389/fchem.2021.774977https://doaj.org/article/bdd32c1de0a84da0ac7d7a280a820b0c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.774977/fullhttps://doaj.org/toc/2296-2646Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry.Xiang ZhangShuning ZhangSongfeng ZhaoXuan WangBo LiuHongtao XuFrontiers Media S.A.articlenatural productclick chemistrydrug discoverymodular synthesistriazolesulfur(VI) fluoride exchangeChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange Chemistry QD1-999
spellingShingle	natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange Chemistry QD1-999 Xiang Zhang Shuning Zhang Songfeng Zhao Xuan Wang Bo Liu Hongtao Xu Click Chemistry in Natural Product Modification
description	Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry.
format	article
author	Xiang Zhang Shuning Zhang Songfeng Zhao Xuan Wang Bo Liu Hongtao Xu
author_facet	Xiang Zhang Shuning Zhang Songfeng Zhao Xuan Wang Bo Liu Hongtao Xu
author_sort	Xiang Zhang
title	Click Chemistry in Natural Product Modification
title_short	Click Chemistry in Natural Product Modification
title_full	Click Chemistry in Natural Product Modification
title_fullStr	Click Chemistry in Natural Product Modification
title_full_unstemmed	Click Chemistry in Natural Product Modification
title_sort	click chemistry in natural product modification
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bdd32c1de0a84da0ac7d7a280a820b0c
work_keys_str_mv	AT xiangzhang clickchemistryinnaturalproductmodification AT shuningzhang clickchemistryinnaturalproductmodification AT songfengzhao clickchemistryinnaturalproductmodification AT xuanwang clickchemistryinnaturalproductmodification AT boliu clickchemistryinnaturalproductmodification AT hongtaoxu clickchemistryinnaturalproductmodification
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Click Chemistry in Natural Product Modification

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