Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis

Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis

Objective: To compare the efficacy of axillary radiotherapy (ART) with that of completion axillary lymph node dissection (cALND) in clinically node-negative breast cancer patients with a positive sentinel lymph node. Methods: A literature search was performed in PubMed, EMBASE and Cochrane Library b...

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Autores principales: Min Zhao, Wei-Guang Liu, Lei Zhang, Zi-Ning Jin, Zhan Li, Cheng Liu, Dong-Bao Li, Ying Ma, Jing-Wen Zhang, Feng Jin, Bo Chen
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2017
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/bdd32f31bcf14ad39505e45553e5ad46
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spelling oai:doaj.org-article:bdd32f31bcf14ad39505e45553e5ad462021-12-02T13:35:02ZCan axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis2095-882X10.1016/j.cdtm.2017.01.005https://doaj.org/article/bdd32f31bcf14ad39505e45553e5ad462017-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X1630069Xhttps://doaj.org/toc/2095-882XObjective: To compare the efficacy of axillary radiotherapy (ART) with that of completion axillary lymph node dissection (cALND) in clinically node-negative breast cancer patients with a positive sentinel lymph node. Methods: A literature search was performed in PubMed, EMBASE and Cochrane Library by using the search terms âbreast cancerâ, âsentinel lymph node biopsyâ, âaxillary radiotherapyâ or âregional node irradiationâ for articles published between 2004 and 2016. Only randomized controlled trials that included patients with positive sentinel nodes were included in the meta-analysis. Results: Two randomized controlled trials and three retrospective studies were identified. The reported overall survival rate (hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 0.75â1.43, P = 0.365), disease-free survival rate (HR = 1.01, 95% CI: 0.58â1.45, P = 0.144), and axillary recurrence rate (1.2% and 0.4%, and 1.3% and 0.8%, respectively) were similar in both groups. The absence of knowledge on the extent of nodal involvement in the ART group appeared to have no major impact on the administration of adjuvant systemic therapy. Conclusions: ART is not inferior to cALND in the patients with clinically node-negative breast cancer who had a positive sentinel lymph node. Information obtained by using cALND after SLNB may have no major impact on the administration of adjuvant systemic therapy. Keywords: Breast cancer, Sentinel lymph node biopsy, Completion axillary lymph node dissection, Axillary radiotherapy, Meta-analysisMin ZhaoWei-Guang LiuLei ZhangZi-Ning JinZhan LiCheng LiuDong-Bao LiYing MaJing-Wen ZhangFeng JinBo ChenKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 1, Pp 41-50 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Min Zhao
Wei-Guang Liu
Lei Zhang
Zi-Ning Jin
Zhan Li
Cheng Liu
Dong-Bao Li
Ying Ma
Jing-Wen Zhang
Feng Jin
Bo Chen
Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis
description Objective: To compare the efficacy of axillary radiotherapy (ART) with that of completion axillary lymph node dissection (cALND) in clinically node-negative breast cancer patients with a positive sentinel lymph node. Methods: A literature search was performed in PubMed, EMBASE and Cochrane Library by using the search terms âbreast cancerâ, âsentinel lymph node biopsyâ, âaxillary radiotherapyâ or âregional node irradiationâ for articles published between 2004 and 2016. Only randomized controlled trials that included patients with positive sentinel nodes were included in the meta-analysis. Results: Two randomized controlled trials and three retrospective studies were identified. The reported overall survival rate (hazard ratio [HR] = 1.09, 95% confidence interval [CI]: 0.75â1.43, P = 0.365), disease-free survival rate (HR = 1.01, 95% CI: 0.58â1.45, P = 0.144), and axillary recurrence rate (1.2% and 0.4%, and 1.3% and 0.8%, respectively) were similar in both groups. The absence of knowledge on the extent of nodal involvement in the ART group appeared to have no major impact on the administration of adjuvant systemic therapy. Conclusions: ART is not inferior to cALND in the patients with clinically node-negative breast cancer who had a positive sentinel lymph node. Information obtained by using cALND after SLNB may have no major impact on the administration of adjuvant systemic therapy. Keywords: Breast cancer, Sentinel lymph node biopsy, Completion axillary lymph node dissection, Axillary radiotherapy, Meta-analysis
format article
author Min Zhao
Wei-Guang Liu
Lei Zhang
Zi-Ning Jin
Zhan Li
Cheng Liu
Dong-Bao Li
Ying Ma
Jing-Wen Zhang
Feng Jin
Bo Chen
author_facet Min Zhao
Wei-Guang Liu
Lei Zhang
Zi-Ning Jin
Zhan Li
Cheng Liu
Dong-Bao Li
Ying Ma
Jing-Wen Zhang
Feng Jin
Bo Chen
author_sort Min Zhao
title Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis
title_short Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis
title_full Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis
title_fullStr Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis
title_full_unstemmed Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis
title_sort can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? a systematic review and meta-analysis
publisher KeAi Communications Co., Ltd.
publishDate 2017
url https://doaj.org/article/bdd32f31bcf14ad39505e45553e5ad46
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