Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals

Numerous fluorescent Zn2+ sensors are available but most are unsuitable to detect physiological dynamics of cytosolic Zn2+. In this study, the authors present a genetically encoded sensor with sub-nanomolar sensitivity and show that Zn2 + is released from endolysosomal vesicles via TRPML1 in neurons...

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Autores principales:	Taylor F. Minckley, Chen Zhang, Dylan H. Fudge, Anna M. Dischler, Kate D. LeJeune, Haoxing Xu, Yan Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdd423d600014470aac82b947c767af4
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spelling	oai:doaj.org-article:bdd423d600014470aac82b947c767af42021-12-02T17:32:56ZSub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals10.1038/s41467-019-12761-x2041-1723https://doaj.org/article/bdd423d600014470aac82b947c767af42019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12761-xhttps://doaj.org/toc/2041-1723Numerous fluorescent Zn2+ sensors are available but most are unsuitable to detect physiological dynamics of cytosolic Zn2+. In this study, the authors present a genetically encoded sensor with sub-nanomolar sensitivity and show that Zn2 + is released from endolysosomal vesicles via TRPML1 in neurons.Taylor F. MinckleyChen ZhangDylan H. FudgeAnna M. DischlerKate D. LeJeuneHaoxing XuYan QinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taylor F. Minckley Chen Zhang Dylan H. Fudge Anna M. Dischler Kate D. LeJeune Haoxing Xu Yan Qin Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
description	Numerous fluorescent Zn2+ sensors are available but most are unsuitable to detect physiological dynamics of cytosolic Zn2+. In this study, the authors present a genetically encoded sensor with sub-nanomolar sensitivity and show that Zn2 + is released from endolysosomal vesicles via TRPML1 in neurons.
format	article
author	Taylor F. Minckley Chen Zhang Dylan H. Fudge Anna M. Dischler Kate D. LeJeune Haoxing Xu Yan Qin
author_facet	Taylor F. Minckley Chen Zhang Dylan H. Fudge Anna M. Dischler Kate D. LeJeune Haoxing Xu Yan Qin
author_sort	Taylor F. Minckley
title	Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
title_short	Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
title_full	Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
title_fullStr	Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
title_full_unstemmed	Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals
title_sort	sub-nanomolar sensitive gznp3 reveals trpml1-mediated neuronal zn2+ signals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bdd423d600014470aac82b947c767af4
work_keys_str_mv	AT taylorfminckley subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals AT chenzhang subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals AT dylanhfudge subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals AT annamdischler subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals AT katedlejeune subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals AT haoxingxu subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals AT yanqin subnanomolarsensitivegznp3revealstrpml1mediatedneuronalzn2signals
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Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals

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