Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment

Objective: To explore the relationship between white matter changes and olfactory ability among patients with mild cognitive impairment (MCI) and to develop a tool to predict the development of Alzheimer’s disease among patients with MCI.Methods: The Montreal Cognitive Assessment (MoCA) was used for...

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Autores principales:	Yongjia Shao, Zijian Wang, Bin Ji, Hang Qi, Shangci Hao, Gang Li, Yue Zhang, Qian Xi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diffusion tensor imaging tract-based spatial statistics mild cognitive impairment Alzheimer’s disease olfactory dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/bdd5d1ca4ed64f01b8171d929cdecbee
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spelling	oai:doaj.org-article:bdd5d1ca4ed64f01b8171d929cdecbee2021-11-30T12:10:40ZDiffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment1663-436510.3389/fnagi.2021.765432https://doaj.org/article/bdd5d1ca4ed64f01b8171d929cdecbee2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.765432/fullhttps://doaj.org/toc/1663-4365Objective: To explore the relationship between white matter changes and olfactory ability among patients with mild cognitive impairment (MCI) and to develop a tool to predict the development of Alzheimer’s disease among patients with MCI.Methods: The Montreal Cognitive Assessment (MoCA) was used for cognitive assessments, and the 70% isopropanol test paper was used to evaluate olfactory function. Tract-based spatial statistics, based on the diffusion tensor imaging technology, were used to obtain relevant parameters, and behavioral and imaging results were compared between patients with MCI (n = 36) and healthy older adults (n = 32).Results: The olfactory ability of MCI patients was lower overall, which was positively correlated with the MoCA score. Fractional anisotropy (FA) changes significantly of all parameters. Lower FA regions were mainly located in the corpus callosum, the orbitofrontal gyrus, and the left occipital lobe. The olfactory score was significantly correlated with the FA value of the orbitofrontal gyrus. Fibrous connections in several brain regions, such as the entorhinal cortex, were stronger in patients with MCI.Conclusion: The olfactory ability of MCI patients in our group was positively correlated with the neuropsychological scale results. Impairment in olfactory function was superior to memory deficits for predicting cognitive decline among cognitively intact participants. The fibrous connections in several brain regions, such as the entorhinal cortex, were higher in patients with MCI, which suggested that there may be a compensatory mechanism in the olfactory pathway in MCI patients. The decline in olfactory function may be a significant and useful indicator of neuropathological changes in MCI patients and an effective marker for the development of cognitive decline and dementia.Yongjia ShaoZijian WangBin JiHang QiShangci HaoGang LiYue ZhangQian XiFrontiers Media S.A.articlediffusion tensor imagingtract-based spatial statisticsmild cognitive impairmentAlzheimer’s diseaseolfactory dysfunctionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diffusion tensor imaging tract-based spatial statistics mild cognitive impairment Alzheimer’s disease olfactory dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	diffusion tensor imaging tract-based spatial statistics mild cognitive impairment Alzheimer’s disease olfactory dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yongjia Shao Zijian Wang Bin Ji Hang Qi Shangci Hao Gang Li Yue Zhang Qian Xi Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment
description	Objective: To explore the relationship between white matter changes and olfactory ability among patients with mild cognitive impairment (MCI) and to develop a tool to predict the development of Alzheimer’s disease among patients with MCI.Methods: The Montreal Cognitive Assessment (MoCA) was used for cognitive assessments, and the 70% isopropanol test paper was used to evaluate olfactory function. Tract-based spatial statistics, based on the diffusion tensor imaging technology, were used to obtain relevant parameters, and behavioral and imaging results were compared between patients with MCI (n = 36) and healthy older adults (n = 32).Results: The olfactory ability of MCI patients was lower overall, which was positively correlated with the MoCA score. Fractional anisotropy (FA) changes significantly of all parameters. Lower FA regions were mainly located in the corpus callosum, the orbitofrontal gyrus, and the left occipital lobe. The olfactory score was significantly correlated with the FA value of the orbitofrontal gyrus. Fibrous connections in several brain regions, such as the entorhinal cortex, were stronger in patients with MCI.Conclusion: The olfactory ability of MCI patients in our group was positively correlated with the neuropsychological scale results. Impairment in olfactory function was superior to memory deficits for predicting cognitive decline among cognitively intact participants. The fibrous connections in several brain regions, such as the entorhinal cortex, were higher in patients with MCI, which suggested that there may be a compensatory mechanism in the olfactory pathway in MCI patients. The decline in olfactory function may be a significant and useful indicator of neuropathological changes in MCI patients and an effective marker for the development of cognitive decline and dementia.
format	article
author	Yongjia Shao Zijian Wang Bin Ji Hang Qi Shangci Hao Gang Li Yue Zhang Qian Xi
author_facet	Yongjia Shao Zijian Wang Bin Ji Hang Qi Shangci Hao Gang Li Yue Zhang Qian Xi
author_sort	Yongjia Shao
title	Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment
title_short	Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment
title_full	Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment
title_fullStr	Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment
title_full_unstemmed	Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment
title_sort	diffusion tensor imaging study of olfactory identification deficit in patients with mild cognitive impairment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bdd5d1ca4ed64f01b8171d929cdecbee
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Diffusion Tensor Imaging Study of Olfactory Identification Deficit in Patients With Mild Cognitive Impairment

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