COMPARISON OF ORAL (20 µG 2 HOURLY) VERSUS VAGINAL (25 µG 6 HOURLY) MISOPROSTOL FOR INDUCTION OF LABOUR IN TERM PREGNANCIES
Objective: To compare the outcome of oral misoprostol (20µg 2 hourly) with vaginal misoprostol (25µg 6hourly) for induction of labour in term pregnancies, in terms of frequency of vaginal delivery and cesarean section. Study Design: Randomized clinical trial. Place and Duration of Study: Depar...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Army Medical College Rawalpindi
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/bddd5106f1c44b1c8fc5a2c1c3deeff6 |
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| Sumario: | Objective: To compare the outcome of oral misoprostol (20µg 2 hourly) with vaginal misoprostol (25µg 6hourly) for induction of labour in term pregnancies, in terms of frequency of vaginal delivery and cesarean section.
Study Design: Randomized clinical trial.
Place and Duration of Study: Department of Gynecology and Obstetrics, Unit II, Maternal and Child Health Centre, Pakistan Institute of Medical Sciences, Islamabad from, Jan to Dec 2015.
Subjects: All pregnant women at term (>37 weeks gestation) with obstetric and medical indication for induction of labour and having Bishop Score ≤6 were included in this study. Parity ≥4, previous history of obstetric and gynecological surgery and suspected cephalopelvic disproportion were excluded.
Material and Methods: The study was conducted after approval from the ethical committee of the hospital. The subjects fulfilling inclusion criteria were enrolled after informed consent. The women randomized to group A received 20 ug oral misoprostol 2 hourly orally up to a maximum of 12 doses and the women randomized to group B received 25 micro-grammisoprostol vaginally and was repeated at 6 hours interval upto a maximum of 4 doses. Randomization was done using lottery method. Data was entered on predesigned proforma and was analyzed using SPSS version 10.
Results: Ninety five women were randomly assigned to group A or B. In oral misoprostol group, 91 (95.8%) had vaginal delivery and 4 (4.2%) women needed C-section compared to 379 (83.2%) vaginal delivery and 16 (16.8%) women need C section in vaginal misoprostol group (p-value0.004).
Conclusion: It is concluded that women randomized to oral misoprostol had better obstetrics outcome as compared to vaginal misoprostol. |
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