CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research

During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. engineer P. falciparum lines with sexual commitment r...

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Autores principales:	Sylwia D. Boltryk, Armin Passecker, Arne Alder, Eilidh Carrington, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Alex van der Starre, Hans-Peter Beck, Robert W. Sauerwein, Taco W. A. Kooij, Nicolas M. B. Brancucci, Nicholas I. Proellochs, Tim-Wolf Gilberger, Till S. Voss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bdde91798fe34a80b40c88b2bfa92cdd
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spelling	oai:doaj.org-article:bdde91798fe34a80b40c88b2bfa92cdd2021-12-02T18:50:57ZCRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research10.1038/s41467-021-24954-42041-1723https://doaj.org/article/bdde91798fe34a80b40c88b2bfa92cdd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24954-4https://doaj.org/toc/2041-1723During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. engineer P. falciparum lines with sexual commitment rates of 75% to promote future studies on gametocyte biology.Sylwia D. BoltrykArmin PasseckerArne AlderEilidh CarringtonMarga van de Vegte-BolmerGeert-Jan van GemertAlex van der StarreHans-Peter BeckRobert W. SauerweinTaco W. A. KooijNicolas M. B. BrancucciNicholas I. ProellochsTim-Wolf GilbergerTill S. VossNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sylwia D. Boltryk Armin Passecker Arne Alder Eilidh Carrington Marga van de Vegte-Bolmer Geert-Jan van Gemert Alex van der Starre Hans-Peter Beck Robert W. Sauerwein Taco W. A. Kooij Nicolas M. B. Brancucci Nicholas I. Proellochs Tim-Wolf Gilberger Till S. Voss CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
description	During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. engineer P. falciparum lines with sexual commitment rates of 75% to promote future studies on gametocyte biology.
format	article
author	Sylwia D. Boltryk Armin Passecker Arne Alder Eilidh Carrington Marga van de Vegte-Bolmer Geert-Jan van Gemert Alex van der Starre Hans-Peter Beck Robert W. Sauerwein Taco W. A. Kooij Nicolas M. B. Brancucci Nicholas I. Proellochs Tim-Wolf Gilberger Till S. Voss
author_facet	Sylwia D. Boltryk Armin Passecker Arne Alder Eilidh Carrington Marga van de Vegte-Bolmer Geert-Jan van Gemert Alex van der Starre Hans-Peter Beck Robert W. Sauerwein Taco W. A. Kooij Nicolas M. B. Brancucci Nicholas I. Proellochs Tim-Wolf Gilberger Till S. Voss
author_sort	Sylwia D. Boltryk
title	CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
title_short	CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
title_full	CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
title_fullStr	CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
title_full_unstemmed	CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research
title_sort	crispr/cas9-engineered inducible gametocyte producer lines as a valuable tool for plasmodium falciparum malaria transmission research
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bdde91798fe34a80b40c88b2bfa92cdd
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CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research

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