TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients...

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Autores principales:	Paloma Riquelme, Jan Haarer, Anja Kammler, Lisa Walter, Stefan Tomiuk, Norbert Ahrens, Anja K. Wege, Ivan Goecze, Daniel Zecher, Bernhard Banas, Rainer Spang, Fred Fändrich, Manfred B. Lutz, Birgit Sawitzki, Hans J. Schlitt, Jordi Ochando, Edward K. Geissler, James A. Hutchinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bde1072b3b4842efb0f1df25fc4a3f9e
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spelling	oai:doaj.org-article:bde1072b3b4842efb0f1df25fc4a3f9e2021-12-02T15:34:42ZTIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity10.1038/s41467-018-05167-82041-1723https://doaj.org/article/bde1072b3b4842efb0f1df25fc4a3f9e2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05167-8https://doaj.org/toc/2041-1723Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients.Paloma RiquelmeJan HaarerAnja KammlerLisa WalterStefan TomiukNorbert AhrensAnja K. WegeIvan GoeczeDaniel ZecherBernhard BanasRainer SpangFred FändrichManfred B. LutzBirgit SawitzkiHans J. SchlittJordi OchandoEdward K. GeisslerJames A. HutchinsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paloma Riquelme Jan Haarer Anja Kammler Lisa Walter Stefan Tomiuk Norbert Ahrens Anja K. Wege Ivan Goecze Daniel Zecher Bernhard Banas Rainer Spang Fred Fändrich Manfred B. Lutz Birgit Sawitzki Hans J. Schlitt Jordi Ochando Edward K. Geissler James A. Hutchinson TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
description	Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients.
format	article
author	Paloma Riquelme Jan Haarer Anja Kammler Lisa Walter Stefan Tomiuk Norbert Ahrens Anja K. Wege Ivan Goecze Daniel Zecher Bernhard Banas Rainer Spang Fred Fändrich Manfred B. Lutz Birgit Sawitzki Hans J. Schlitt Jordi Ochando Edward K. Geissler James A. Hutchinson
author_facet	Paloma Riquelme Jan Haarer Anja Kammler Lisa Walter Stefan Tomiuk Norbert Ahrens Anja K. Wege Ivan Goecze Daniel Zecher Bernhard Banas Rainer Spang Fred Fändrich Manfred B. Lutz Birgit Sawitzki Hans J. Schlitt Jordi Ochando Edward K. Geissler James A. Hutchinson
author_sort	Paloma Riquelme
title	TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
title_short	TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
title_full	TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
title_fullStr	TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
title_full_unstemmed	TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
title_sort	tigit+ itregs elicited by human regulatory macrophages control t cell immunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bde1072b3b4842efb0f1df25fc4a3f9e
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TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

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