Artificial strain of human prions created in vitro

Artificial strain of human prions created in vitro

Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.

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Autores principales: Chae Kim, Xiangzhu Xiao, Shugui Chen, Tracy Haldiman, Vitautas Smirnovas, Diane Kofskey, Miriam Warren, Krystyna Surewicz, Nicholas R. Maurer, Qingzhong Kong, Witold Surewicz, Jiri G. Safar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/bde375ffd18941009f755ddc28b0cf33
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spelling oai:doaj.org-article:bde375ffd18941009f755ddc28b0cf332021-12-02T16:49:35ZArtificial strain of human prions created in vitro10.1038/s41467-018-04584-z2041-1723https://doaj.org/article/bde375ffd18941009f755ddc28b0cf332018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04584-zhttps://doaj.org/toc/2041-1723Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.Chae KimXiangzhu XiaoShugui ChenTracy HaldimanVitautas SmirnovasDiane KofskeyMiriam WarrenKrystyna SurewiczNicholas R. MaurerQingzhong KongWitold SurewiczJiri G. SafarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chae Kim
Xiangzhu Xiao
Shugui Chen
Tracy Haldiman
Vitautas Smirnovas
Diane Kofskey
Miriam Warren
Krystyna Surewicz
Nicholas R. Maurer
Qingzhong Kong
Witold Surewicz
Jiri G. Safar
Artificial strain of human prions created in vitro
description Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.
format article
author Chae Kim
Xiangzhu Xiao
Shugui Chen
Tracy Haldiman
Vitautas Smirnovas
Diane Kofskey
Miriam Warren
Krystyna Surewicz
Nicholas R. Maurer
Qingzhong Kong
Witold Surewicz
Jiri G. Safar
author_facet Chae Kim
Xiangzhu Xiao
Shugui Chen
Tracy Haldiman
Vitautas Smirnovas
Diane Kofskey
Miriam Warren
Krystyna Surewicz
Nicholas R. Maurer
Qingzhong Kong
Witold Surewicz
Jiri G. Safar
author_sort Chae Kim
title Artificial strain of human prions created in vitro
title_short Artificial strain of human prions created in vitro
title_full Artificial strain of human prions created in vitro
title_fullStr Artificial strain of human prions created in vitro
title_full_unstemmed Artificial strain of human prions created in vitro
title_sort artificial strain of human prions created in vitro
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/bde375ffd18941009f755ddc28b0cf33
work_keys_str_mv AT chaekim artificialstrainofhumanprionscreatedinvitro
AT xiangzhuxiao artificialstrainofhumanprionscreatedinvitro
AT shuguichen artificialstrainofhumanprionscreatedinvitro
AT tracyhaldiman artificialstrainofhumanprionscreatedinvitro
AT vitautassmirnovas artificialstrainofhumanprionscreatedinvitro
AT dianekofskey artificialstrainofhumanprionscreatedinvitro
AT miriamwarren artificialstrainofhumanprionscreatedinvitro
AT krystynasurewicz artificialstrainofhumanprionscreatedinvitro
AT nicholasrmaurer artificialstrainofhumanprionscreatedinvitro
AT qingzhongkong artificialstrainofhumanprionscreatedinvitro
AT witoldsurewicz artificialstrainofhumanprionscreatedinvitro
AT jirigsafar artificialstrainofhumanprionscreatedinvitro
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