NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease

Trafficking of IgA/commensal complex in the gut has been implicated in inflammatory bowel diseases such as Crohn’s disease, but molecular insights are still lacking. Here the authors show, using mouse model or human cells, that NOD2 mutation increases IgA transport, potentially by altering gut micro...

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Autores principales:	Nicolas Rochereau, Xavier Roblin, Eva Michaud, Rémi Gayet, Blandine Chanut, Fabienne Jospin, Blaise Corthésy, Stéphane Paul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bde4151689be423cb7933743593ce8e2
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spelling	oai:doaj.org-article:bde4151689be423cb7933743593ce8e22021-12-02T14:01:15ZNOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease10.1038/s41467-020-20348-02041-1723https://doaj.org/article/bde4151689be423cb7933743593ce8e22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20348-0https://doaj.org/toc/2041-1723Trafficking of IgA/commensal complex in the gut has been implicated in inflammatory bowel diseases such as Crohn’s disease, but molecular insights are still lacking. Here the authors show, using mouse model or human cells, that NOD2 mutation increases IgA transport, potentially by altering gut microfold cells from the gut, to impact gut inflammation.Nicolas RochereauXavier RoblinEva MichaudRémi GayetBlandine ChanutFabienne JospinBlaise CorthésyStéphane PaulNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Rochereau Xavier Roblin Eva Michaud Rémi Gayet Blandine Chanut Fabienne Jospin Blaise Corthésy Stéphane Paul NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
description	Trafficking of IgA/commensal complex in the gut has been implicated in inflammatory bowel diseases such as Crohn’s disease, but molecular insights are still lacking. Here the authors show, using mouse model or human cells, that NOD2 mutation increases IgA transport, potentially by altering gut microfold cells from the gut, to impact gut inflammation.
format	article
author	Nicolas Rochereau Xavier Roblin Eva Michaud Rémi Gayet Blandine Chanut Fabienne Jospin Blaise Corthésy Stéphane Paul
author_facet	Nicolas Rochereau Xavier Roblin Eva Michaud Rémi Gayet Blandine Chanut Fabienne Jospin Blaise Corthésy Stéphane Paul
author_sort	Nicolas Rochereau
title	NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
title_short	NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
title_full	NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
title_fullStr	NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
title_full_unstemmed	NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
title_sort	nod2 deficiency increases retrograde transport of secretory iga complexes in crohn’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bde4151689be423cb7933743593ce8e2
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NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease

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