The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury

Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular defense responses against toxic and oxidative stress by modulating the expression of genes involved in antioxidant response and drug detoxification. In addition to maintaining redox homeostasis, Nrf2...

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Autores principales:	Ana Mata, Susana Cadenas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardioprotection ischemia–reperfusion injury ischemic conditioning Nrf2 activators oxidative stress reactive oxygen species Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bde4ff33f92a4064b651c0099a31520f
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spelling	oai:doaj.org-article:bde4ff33f92a4064b651c0099a31520f2021-11-11T17:21:35ZThe Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury10.3390/ijms2221119391422-00671661-6596https://doaj.org/article/bde4ff33f92a4064b651c0099a31520f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11939https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular defense responses against toxic and oxidative stress by modulating the expression of genes involved in antioxidant response and drug detoxification. In addition to maintaining redox homeostasis, Nrf2 is also involved in various cellular processes including metabolism and inflammation. Nrf2 activity is tightly regulated at the transcriptional, post-transcriptional and post-translational levels, which allows cells to quickly respond to pathological stress. In the present review, we describe the molecular mechanisms underlying the transcriptional regulation of Nrf2. We also focus on the impact of Nrf2 in cardiac ischemia–reperfusion injury, a condition that stimulates the overproduction of reactive oxygen species. Finally, we analyze the protective effect of several natural and synthetic compounds that induce Nrf2 activation and protect against ischemia–reperfusion injury in the heart and other organs, and their potential clinical application.Ana MataSusana CadenasMDPI AGarticlecardioprotectionischemia–reperfusion injuryischemic conditioningNrf2 activatorsoxidative stressreactive oxygen speciesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11939, p 11939 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardioprotection ischemia–reperfusion injury ischemic conditioning Nrf2 activators oxidative stress reactive oxygen species Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cardioprotection ischemia–reperfusion injury ischemic conditioning Nrf2 activators oxidative stress reactive oxygen species Biology (General) QH301-705.5 Chemistry QD1-999 Ana Mata Susana Cadenas The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury
description	Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that controls cellular defense responses against toxic and oxidative stress by modulating the expression of genes involved in antioxidant response and drug detoxification. In addition to maintaining redox homeostasis, Nrf2 is also involved in various cellular processes including metabolism and inflammation. Nrf2 activity is tightly regulated at the transcriptional, post-transcriptional and post-translational levels, which allows cells to quickly respond to pathological stress. In the present review, we describe the molecular mechanisms underlying the transcriptional regulation of Nrf2. We also focus on the impact of Nrf2 in cardiac ischemia–reperfusion injury, a condition that stimulates the overproduction of reactive oxygen species. Finally, we analyze the protective effect of several natural and synthetic compounds that induce Nrf2 activation and protect against ischemia–reperfusion injury in the heart and other organs, and their potential clinical application.
format	article
author	Ana Mata Susana Cadenas
author_facet	Ana Mata Susana Cadenas
author_sort	Ana Mata
title	The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury
title_short	The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury
title_full	The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury
title_fullStr	The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury
title_full_unstemmed	The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury
title_sort	antioxidant transcription factor nrf2 in cardiac ischemia–reperfusion injury
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bde4ff33f92a4064b651c0099a31520f
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The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury

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