Enantiomer-specific activities of an LRH-1 and SF-1 dual agonist

Abstract Chirality is an important consideration in drug development: it can influence recognition of the intended target, pharmacokinetics, and off-target effects. Here, we investigate how chirality affects the activity and mechanism of action of RJW100, a racemic agonist of the nuclear receptors l...

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Autores principales: Suzanne G. Mays, Józef Stec, Xu Liu, Emma H. D’Agostino, Richard J. Whitby, Eric A. Ortlund
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bde5e80a95114cbbb7800f850e004f61
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