A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid

Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the trifluoroethylation of primary and secondary amine...

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Autores principales:	Keith G. Andrews, Radmila Faizova, Ross M. Denton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bde6562d81114219aed1b074eaa09747
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spelling	oai:doaj.org-article:bde6562d81114219aed1b074eaa097472021-12-02T14:42:27ZA practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid10.1038/ncomms159132041-1723https://doaj.org/article/bde6562d81114219aed1b074eaa097472017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15913https://doaj.org/toc/2041-1723Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the trifluoroethylation of primary and secondary amines.Keith G. AndrewsRadmila FaizovaRoss M. DentonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keith G. Andrews Radmila Faizova Ross M. Denton A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
description	Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the trifluoroethylation of primary and secondary amines.
format	article
author	Keith G. Andrews Radmila Faizova Ross M. Denton
author_facet	Keith G. Andrews Radmila Faizova Ross M. Denton
author_sort	Keith G. Andrews
title	A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
title_short	A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
title_full	A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
title_fullStr	A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
title_full_unstemmed	A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
title_sort	practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bde6562d81114219aed1b074eaa09747
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A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid

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