Synthetic Biology Advanced Natural Product Discovery

A wide variety of bacteria, fungi and plants can produce bioactive secondary metabolites, which are often referred to as natural products. With the rapid development of DNA sequencing technology and bioinformatics, a large number of putative biosynthetic gene clusters have been reported. However, on...

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Autores principales:	Junyang Wang, Jens Nielsen, Zihe Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	natural products biosynthetic gene clusters synthetic biology genome mining and engineering strategies design-build-test-learn (DBTL) cycle Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/bde96816a3ab4a09b257da9b1cb807d2
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spelling	oai:doaj.org-article:bde96816a3ab4a09b257da9b1cb807d22021-11-25T18:20:54ZSynthetic Biology Advanced Natural Product Discovery10.3390/metabo111107852218-1989https://doaj.org/article/bde96816a3ab4a09b257da9b1cb807d22021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/785https://doaj.org/toc/2218-1989A wide variety of bacteria, fungi and plants can produce bioactive secondary metabolites, which are often referred to as natural products. With the rapid development of DNA sequencing technology and bioinformatics, a large number of putative biosynthetic gene clusters have been reported. However, only a limited number of natural products have been discovered, as most biosynthetic gene clusters are not expressed or are expressed at extremely low levels under conventional laboratory conditions. With the rapid development of synthetic biology, advanced genome mining and engineering strategies have been reported and they provide new opportunities for discovery of natural products. This review discusses advances in recent years that can accelerate the design, build, test, and learn (DBTL) cycle of natural product discovery, and prospects trends and key challenges for future research directions.Junyang WangJens NielsenZihe LiuMDPI AGarticlenatural productsbiosynthetic gene clusterssynthetic biologygenome mining and engineering strategiesdesign-build-test-learn (DBTL) cycleMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 785, p 785 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural products biosynthetic gene clusters synthetic biology genome mining and engineering strategies design-build-test-learn (DBTL) cycle Microbiology QR1-502
spellingShingle	natural products biosynthetic gene clusters synthetic biology genome mining and engineering strategies design-build-test-learn (DBTL) cycle Microbiology QR1-502 Junyang Wang Jens Nielsen Zihe Liu Synthetic Biology Advanced Natural Product Discovery
description	A wide variety of bacteria, fungi and plants can produce bioactive secondary metabolites, which are often referred to as natural products. With the rapid development of DNA sequencing technology and bioinformatics, a large number of putative biosynthetic gene clusters have been reported. However, only a limited number of natural products have been discovered, as most biosynthetic gene clusters are not expressed or are expressed at extremely low levels under conventional laboratory conditions. With the rapid development of synthetic biology, advanced genome mining and engineering strategies have been reported and they provide new opportunities for discovery of natural products. This review discusses advances in recent years that can accelerate the design, build, test, and learn (DBTL) cycle of natural product discovery, and prospects trends and key challenges for future research directions.
format	article
author	Junyang Wang Jens Nielsen Zihe Liu
author_facet	Junyang Wang Jens Nielsen Zihe Liu
author_sort	Junyang Wang
title	Synthetic Biology Advanced Natural Product Discovery
title_short	Synthetic Biology Advanced Natural Product Discovery
title_full	Synthetic Biology Advanced Natural Product Discovery
title_fullStr	Synthetic Biology Advanced Natural Product Discovery
title_full_unstemmed	Synthetic Biology Advanced Natural Product Discovery
title_sort	synthetic biology advanced natural product discovery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bde96816a3ab4a09b257da9b1cb807d2
work_keys_str_mv	AT junyangwang syntheticbiologyadvancednaturalproductdiscovery AT jensnielsen syntheticbiologyadvancednaturalproductdiscovery AT ziheliu syntheticbiologyadvancednaturalproductdiscovery
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Synthetic Biology Advanced Natural Product Discovery

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